Sodium Benzoate is a chemical compound and is used as a preservative in the food industry and in cosmetics. It has contrasting properties to bacteria and fungi. Sodium benzoate is an effective and sa ...

Read the full Tiiip

(Send your comment)

Sodium Benzoate is a chemical compound and is used as a preservative in the food industry and in cosmetics. It has contrasting properties to bacteria and fungi.

Sodium benzoate is an effective and safe chemical compound, so much so that treatment of acute episodes of hyperammonemia in urea cycle enzyme disorders is injected intravenously (1).

Other studies have confirmed, even if only in vitro, the efficacy in the treatment of multiple sclerosis (2), it proved to be a potential cardiovascular drug and exerts a powerful neuroprotective effect against transient and long-term ischemic stroke in rats (3 ).

It is widely used in many foods and soft drinks as a preservative and is metabolized within the mitochondria to be eliminated by the kidneys.

Ingestion of sodium benzoate is generally considered to be safe and does not have an acute adverse effect on glucose homeostasis (4).

References_________________________________

(1) Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study.

Husson MC, Schiff M, Fouilhoux A, Cano A, Dobbelaere D, Brassier A, Mention K, Arnoux JB, Feillet F, Chabrol B, Guffon N, Elie C, de Lonlay P.   -  Orphanet J Rare Dis. 2016 Sep

(2) In Vitro Effects of Sodium Benzoate on Th1/Th2 Deviation in Patients with Multiple Sclerosis.

Rezaei N, Amirghofran Z, Nikseresht A, Ashjazade N, Zoghi S, Tahvili S, Kamali-Sarvestani E.  -  Immunol Invest. 2016 Oct

(3) Preclinical Pharmacokinetics, Tissue Distribution, and Plasma Protein Binding of Sodium (±)-5-Bromo-2-(α-Hydroxypentyl) Benzoate (BZP), an Innovative Potent Anti-ischemic Stroke Agent.

Tian X, Li HM, Wei JY, Liu BJ, Zhang YH, Wang GJ, Chang JB, Qiao HL.  -  Front Pharmacol. 2016 Aug

(4) Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.

Lennerz BS, Vafai SB, Delaney NF, Clish CB, Deik AA, Pierce KA, Ludwig DS, Mootha VK.  -  Mol Genet Metab. 2015 Jan

 

Sign up to vote this object, vote his reviews and to contribute to Tiiips.Evaluate