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 | "Descrizione" by A_Partyns (12876 pt) | 2023-Dec-16 17:36 |
| Evaluation | N. Experts | Evaluation | N. Experts |
|---|---|---|---|
| 1 | 6 | ||
| 2 | 7 | ||
| 3 | 8 | ||
| 4 | 9 | ||
| 5 | 10 |
Disodium Laureth Sulfosuccinate is a chemical compound belonging to a group of salts of sulphated ethoxylated alcohols. Although it is treated with ethylene oxide, there are currently no studies revealing any danger to human health.
The name describes the structure of the molecule:
The synthesis process takes place in different steps:
It appears as a colourless to slightly pale viscous liquid.
What it is used for and where it is used
Cosmetics
It is a cationic surfactant. It is used in toothpastes, shampoos etc. because of its medium cleaning capacity, weak degreasing power, but with excellent solubilisation and viscosity regulation functions. Reduces irritation potentially induced by other anionic surfactants. Also used as emulsifier, dispersant, wetting agent.
Surfactant Foam booster
Their function is to introduce gas bubbles into the water for a purely aesthetic factor, which does not affect the cleaning process, but only satisfies the commercial aspect of the detergent by helping to spread the detergent on the hair. This helps in the commercial success of a shampoo formulation. Since sebum has an inhibiting action on the bubble, more foam is produced in the second shampoo.
Surfactant Hydrotrope(solubilizing agents)
A compound that has the property of facilitating the miscibility of other compounds that are poorly soluble in water and does not form micelles in the solubilisation process, even with a chemical reaction of complexation or molecular aggregation. The two fundamental solubilisation factors are the hydrotropic-solute association mediated by the depression of water activity and ionic dissociation.
Industry
Disodium Laureth Sulfosuccinate is used as a detergent in industry.
Medicine
Excipient in pharmaceutical preparations. Surgical detergent.
Properties:
Safety
The most relevant studies on this ingredient have been selected with a summary of their contents:
Disodium Laureth Sulfosuccinate studies
Typical optimal commercial product characteristics Disodium laureth sulfosuccinate (30%)
| Appearance | Colorless to yellow |
| PSA | 159.70000 |
| LogP | 2.63490 |
| Liquid | 38.0-42.0% |
| Solid content(%) | ≤34.5 |
| Viscosity | 8.5 ~10.5 |
| pH (1%water) | 5.0~7.0 |
| Na2SO3(﹪) | ≤0.2 |
| Na2SO4(%) | ≤0.2 |
| Foam(mm) | ≤0.3 |
| Hazen | ≤40 |
| Foaming power mm | ≥150 |
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Synonyms:
References_________________________________________________________________________
(1) Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Alkyl PEG Sulfosuccinates as Used in Cosmetics. Int J Toxicol. 2015 Sep;34(2 Suppl):70S-83S. doi: 10.1177/1091581815594755.
Abstract. The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the safety of alkyl polyethylene glycol (PEG) sulfosuccinates, which function in cosmetics mostly as surfactants/cleansing agents. Although these ingredients may cause ocular and skin irritation, dermal penetration is unlikely because of the substantial polarity and molecular size of these ingredients. The Panel considered the negative oral carcinogenicity and reproductive and developmental toxicity data on chemically related laureths (PEG lauryl ethers) and negative repeated dose toxicity and skin sensitization data on disodium laureth sulfosuccinate supported the safety of these alkyl PEG sulfosuccinates in cosmetic products, but. The CIR Expert Panel concluded that the alkyl PEG sulfosuccinates are safe in the present practices of use and concentration when formulated to be nonirritating.
(2) Santucci B, Cannistraci C, Lesnoni I, Ferraro C, Rocco MG, Dell'Anna L, Giannarelli D, Cristaudo A. Cutaneous response to irritants. Contact Dermatitis. 2003 Feb;48(2):69-73. doi: 10.1034/j.1600-0536.2003.480203.x
Abstract. We evaluated the role of pre-existing dermatitis in the response to irritants by patch testing the skin of 40 healthy volunteers and the uninvolved skin of 480 subjects for 2 days. These latter were affected by active atopic dermatitis, psoriasis, eczema with positive and negative patch test reactions, urticaria and generalized pruritus. A first panel containing 15 micro L of aq. solutions of disodium laureth sulfosuccinate (NaLSS) 5% and 10%, potassium cocoate (KCC) 5%, potassium oleate (KOL) 5%, zinc coleth sulphate (ZnCS) 5%, sodium mireth sulphate (NaMS) 5%, sodium cocoamphoacetate (NaCCAA) 3% and 5%, was simultaneously applied to 1 site on the upper back. The results, scored by visual assessment, were compared to those observed when testing on the opposite side a second panel containing 15 micro L of aq. solutions of 3 well-known irritants, benzalkonium chloride (BAK) 1%, sodium lauryl sulphate (SLS) 1%, and dimethylsulphoxide (DMSO) 10%. Whilst the substances of the first panel and DMSO gave, on the whole, a scarce number of positive responses in all the tested groups, more evident differences in number, percent and mean intensity of the positive responses to BAK and SLS were found between the different groups. Although some of them seemed statistically significant, when the same values were evaluated by means of chi2 and Student t-test, they did not differ in a statistically significant way from the values found in healthy subjects. The results of this study seem to indicate that the substances of the first panel have a chemical structure that makes them quite safe in real-life conditions. In contrast, BAK and SLS have chemical properties that condition the number and intensity of the responses, making the role exerted by the pre-existing dermatosis quite marginal. In particular, there is no proof that the healthy skin of active atopic subjects is the most susceptible to the irritating effects of the tested substances.
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