Compendium of the most significant studies with reference to properties, intake, effects.

Lian R, Lu Y, Qi J, Tan Y, Niu M, Guan P, Hu F, Wu W. Silymarin glyceryl monooleate/poloxamer 407 liquid crystalline matrices: physical characterization and enhanced oral bioavailability. AAPS PharmSciTech. 2011 Dec;12(4):1234-40. doi: 10.1208/s12249-011-9666-2.

Abstract. The main purpose of this study was to prepare silymarin glyceryl monooleate/poloxamer 407 liquid crystalline matrices (GMO/P407 LCM) to improve the oral bioavailability of silymarin.

Eskinazi-Budge A, Manickavasagam D, Czech T, Novak K, Kunzler J, Oyewumi MO. Preparation of emulsifying wax/glyceryl monooleate nanoparticles and evaluation as a delivery system for repurposing simvastatin in bone regeneration. Drug Dev Ind Pharm. 2018 Oct;44(10):1583-1590. doi: 10.1080/03639045.2018.1483381.

Abstract. In this study, we have investigated a new lipid nanoparticle (NP) platform that was fabricated using a binary blend of emulsifying wax (Ewax) and glyceryl monooleate (GMO).

 Milak S, Zimmer A. Glycerol monooleate liquid crystalline phases used in drug delivery systems. Int J Pharm. 2015 Jan 30;478(2):569-87. doi: 10.1016/j.ijpharm.2014.11.072.

Abstract. This review presents recent progress in glycerol monooleate liquid crystalline phases used as drug delivery vehicles.

Sadhale Y, Shah JC. Glyceryl monooleate cubic phase gel as chemical stability enhancer of cefazolin and cefuroxime. Pharm Dev Technol. 1998 Nov;3(4):549-56. doi: 10.3109/10837459809028637.

Abstract. The primary objective of this study was to determine the ability of the glyceryl monooleate (GMO) cubic phase gel to protect drugs from chemical instability reactions such as hydrolysis and oxidation.

Ericsson EM, Faxälv L, Weissenrieder A, Askendal A, Lindahl TL, Tengvall P. Glycerol monooleate-blood interactions. Colloids Surf B Biointerfaces. 2009 Jan 1;68(1):20-6. doi: 10.1016/j.colsurfb.2008.09.016.

Abstract. In the present study the initial blood compatibility of glycerol monooleate (GMO)-coated surfaces was evaluated after deposition to surfaces and in bulk. The model surface was silica onto which multiple layers of fibrinogen or human serum albumin (HSA) was immobilized. 

Nguyen TH, Hanley T, Porter CJ, Larson I, Boyd BJ. Phytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water soluble drugs I. Phase behaviour in physiologically-relevant media. J Pharm Pharmacol. 2010 Jul;62(7):844-55. doi: 10.1211/jpp.62.06.0005.

Abstract. The potential utility of liquid crystalline lipid-based formulations in oral drug delivery is expected to depend critically on their structure formation and stability in gastrointestinal fluids. The phase behaviour of lipid-based liquid crystals formed by phytantriol and glyceryl monooleate, known to form a bicontinuous cubic phase in excess water, was therefore assessed in physiologically-relevant simulated gastrointestinal media.

Trickler WJ, Khurana J, Nagvekar AA, Dash AK. Chitosan and glyceryl monooleate nanostructures containing gemcitabine: potential delivery system for pancreatic cancer treatment. AAPS PharmSciTech. 2010 Mar;11(1):392-401. doi: 10.1208/s12249-010-9393-0.

Abstract. The objectives of this study are to enhance cellular accumulation of gemcitabine with chitosan/glyceryl monooleate (GMO) nanostructures, and to provide significant increase in cell death of human pancreatic cancer cells in vitro.