Two clinical studies published in 1974 and 1978 reported positive reactions to Acid Blue 9 between 1% and 14% (1), In vitro laboratory tests have classified this component as mildly irritating to the ...

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Two clinical studies published in 1974 and 1978 reported positive reactions to Acid Blue 9 between 1% and 14% (1),

In vitro laboratory tests have classified this component as mildly irritating to the eyes (2).

For the complete and detailed analysis of other tests carried out, I refer to this official document (3).

Other studies

Biological Effects of Food Coloring in In Vivo and In Vitro Model Systems.
Merinas-Amo R, Martínez-Jurado M, Jurado-Güeto S, Alonso-Moraga Á, Merinas-Amo T.
Foods. 2019 May 24;8(5). pii: E176. doi: 10.3390/foods8050176.

Theoretical Risk Assessment of Dietary Exposure to Brilliant Blue FCF in Chinese Population.
Wang HL, Ding H, Cao P, Zhang JB, Wu D, Tian J.
Biomed Environ Sci. 2019 Feb;32(2):126-129. doi: 10.3967/bes2019.017.

Understanding the performance of a paper-based UV exposure sensor: The photodegradation mechanism of brilliant blue FCF in the presence of TiO2 photocatalysts in both the solid-state and solution.
Khiabani PS, Soeriyadi AH, Nam EV, Peterson JR, Webb JEA, Thordarson P, Donald WA, Gooding JJ.
Rapid Commun Mass Spectrom. 2019 Mar 22. doi: 10.1002/rcm.8442.

Simultaneous Extraction and Determination of Allura Red (E129) and Brilliant Blue FCF (E133) in Foodstuffs by Column Solid-Phase Spectrophotometry.
Bişgin AT.
J AOAC Int. 2018 Jun 12. doi: 10.5740/jaoacint.18-0073.

Determination of Brilliant Blue FCF by a Novel Solid-state ECL Quenching Sensor of Ru(bpy)32+-poly(sulfosalicylic acid)/GCE.
Chen X, Yin J, Zhang C, Lu N, Chen Z.
Anal Sci. 2017;33(10):1123-1128. doi: 10.2116/analsci.33.1123.

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation.
Molica F, Nolli S, Fontana P, Kwak BR.
J Vis Exp. 2017 Apr 6;(122). doi: 10.3791/55525.

Advanced Oxidation of Tartrazine and Brilliant Blue with Pulsed Ultraviolet Light Emitting Diodes.
Scott R, Mudimbi P, Miller ME, Magnuson M, Willison S, Phillips R, Harper WF Jr.
Water Environ Res. 2017 Jan 1;89(1):24-31. doi: 10.2175/106143016X14733681696167

Use of Brilliant Blue FCF during vein graft preparation inhibits intimal hyperplasia.
Osgood MJ, Sexton K, Voskresensky I, Hocking K, Song J, Komalavilas P, Brophy C, Cheung-Flynn J.
J Vasc Surg. 2016 Aug;64(2):471-478. doi: 10.1016/j.jvs.2015.02.028.

References____________________________________________________________

(1) H Mikkelsen, J C Larsen, F Tarding. Hypersensitivity reactions to food colours with special reference to the natural colour Annatto Extract (Butter Colour). Archives of Toxicology, Suppl. 1 141-143 (1978).

(2) Cosmital SA. Assessment of the Eye Irritation Potential of Blue 1 (WR 23312) in the Hen’s Egg Test on the Chorioallantoic Membrane (HET-CAM). Final Report. Study No.HC 141. Marly, Switzerland. Sponsored by Wella AG Darmstadt. 2002.

(3) OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD

PRODUCTS INTENDED FOR CONSUMERS - SCCNFP/0787/04 - CONCERNING  ACID BLUE 9 -

23 April 2004

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