Compendium of the most significant studies with reference to properties, intake, effects.

Gerner E, Almqvist S, Thomsen P, Werthén M, Trobos M. Sodium Salicylate Influences the Pseudomonas aeruginosa Biofilm Structure and Susceptibility Towards Silver. Int J Mol Sci. 2021 Jan 21;22(3):1060. doi: 10.3390/ijms22031060.

Abstract.  Here, we investigated whether inhibition of quorum sensing (QS) by sodium salicylate in different P. aeruginosa strains (QS-competent, QS-mutant, and chronic wound strains) influences biofilm formation and tolerance to silver. 

Klimek VM, Dolezal EK, Smith L, Soff G, Nimer SD. Phase I trial of sodium salicylate in patients with myelodysplastic syndromes and acute myelogenous leukemia. Leuk Res. 2012 May;36(5):570-4. doi: 10.1016/j.leukres.2011.10.023.

Abstract. We examined whether it was possible to safely achieve and maintain salicylate levels known to inhibit NF-κB in vitro in 11 patients with MDS or AML taking sodium salicylate. 

Park HS, Lim YS, Suh JE, Rhu NS, Cho DI, Kim JW. Sodium salicylate sensitivity in an asthmatic patient with aspirin sensitivity. J Korean Med Sci. 1991 Jun;6(2):113-7. doi: 10.3346/jkms.1991.6.2.113.

Abstract. We experienced a case of an aspirin-sensitive asthmatic patient who developed a broncho-obstructive reaction after taking 100 mg of sodium salicylate. The result of this study suggests that sodium salicylate may cross-react with aspirin in aspirin-and tartrazine-sensitive patients.

Watanabe M, Ozeki T, Shibata T, Murakoshi H, Takashima Y, Yuasa H, Okada H. Effect of shape of sodium salicylate particles on physical property and in vitro aerosol performance of granules prepared by pressure swing granulation method. AAPS PharmSciTech. 2003 Dec 16;4(4):E64. doi: 10.1208/pt040464.

Abstract. The purpose of this research was to investigate the effect of the shape of sodium salicylate (SS) particles on the physical properties as well as the in vitro aerosol performance of the granules granulated by the pressure swing granulation method.

Wood NJ, Lowe AS, Walton JP. Sodium salicylate alters temporal integration measured through increasing stimulus presentation rates. Int J Audiol. 2019 Mar;58(3):141-150. doi: 10.1080/14992027.2018.1544424.

Abstract.  High doses of sodium salicylate (SS) are known to induce tinnitus, general hyperexcitability in the central auditory system, and to cause mild hearing loss. We used the auditory brainstem response (ABR) to assess the effects of SS on auditory sensitivity and temporal processing in the auditory nerve and brainstem.