Pancreatic. To investigate the therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis in rats, the healing effects of ellagic acid on inflammatory and oxidat ...

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Pancreatic.

To investigate the therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis in rats, the healing effects of ellagic acid on inflammatory and oxidative stress were confirmed by histopathological and biochemical evaluations of the pancreatic tissue (1).

Parkinson

Ellagic and curcumin are the natural polyphenols having a wide range of pharmacological actions. They have been reported to have their use in various neurological disorders. This study was aimed to evaluate the effect of curcumin and ellagic acid on the activity of monoamine oxidase (MAO), the enzyme responsible for metabolism of monoamine neurotransmitters which are pivotal for neuronal development and function. Curcumin and ellagic acid can be considered a possible source of MAO inhibitor used in the treatment of Parkinson's and other neurological disorders (2).

Colon.

Colon cancer stem cells (CSCs) offer a novel paradigm for colorectal cancer (CRC) treatment and dietary polyphenols may contribute to battle these cells. Specifically, polyphenol-derived colon metabolites have the potential to interact with and affect colon CSCs. We herein report the effects against colon CSCs of two mixtures of ellagitannin (ET) metabolites, ellagic acid (EA) and the gut microbiota-derived urolithins (Uro) at concentrations detected in the human colon tissues following the intake of ET-containing products (pomegranate, walnuts)(3).

Brain.

Context In a previous study, it has been shown that ellagic acid (EA), a polyphenolic compound found in pomegranate and different berries, prevents cognitive and hippocampal long-term potentiation (LTP) impairments induced by traumatic brain injury in rats through antioxidant and anti-inflammatory mechanisms. Objective The present study was conducted to assess the potential of EA as a memory enhancer. Materials and methods The elevated plus maze (EPM) and passive avoidance (PA) paradigm were used to evaluate learning and memory parameters. This study demonstrates that ellagic acid is effective in preventing scopolamine- and diazepam-induced cognitive impairments without altering the animals' locomotion. This suggests the potential of EA application as a useful memory restorative agent in the treatment of dementia seen in elderly persons (4).

References_________________________________

(1) Therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis.
Yılmaz EE, Bozdağ Z, Ibiloğlu I, Arıkanoğlu Z, Yazgan ÜC, Kaplan I, Gümüş M, Atamanalp SS.
Acta Cir Bras. 2016 Jun;31(6):396-401. doi: 10.1590/S0102-865020160060000006.

(2) Kinetics of Inhibition of Monoamine Oxidase Using Curcumin and Ellagic Acid.
Khatri DK, Juvekar AR.
Pharmacogn Mag. 2016 May;12(Suppl 2):S116-20. doi: 10.4103/0973-1296.182168. Epub 2016 May 11.

(3) In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer.
Núñez-Sánchez MÁ, Karmokar A, González-Sarrías A, García-Villalba R, Tomás-Barberán FA, García-Conesa MT, Brown K, Espín JC.
Food Chem Toxicol. 2016 Jun;92:8-16. doi: 10.1016/j.fct.2016.03.011. Epub 2016 Mar 16. 

(4) Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments.
Mansouri MT, Farbood Y, Naghizadeh B, Shabani S, Mirshekar MA, Sarkaki A.
Pharm Biol. 2016 Feb 1:1-7.

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