Components that help combat fatigue are substances that can contribute to improving energy levels and reducing tiredness. Here are some examples

• Vitamin B12. Essential for energy production and nervous system function.
• Iron. Important for the production of hemoglobin, which carries oxygen in the blood.
• Magnesium. Involved in hundreds of biochemical reactions in the body, including energy metabolism (1).
• Omega-3 Fatty Acids. Found in fatty fish, they can improve brain function and reduce fatigue.
• Coenzyme Q10. Helps in energy production at the cellular level (2).
• Vitamin D. Its deficiency is often associated with fatigue and tiredness.
• Water. Good hydration is crucial for maintaining energy and preventing fatigue.
• Ginseng. An adaptogenic plant that can help fight fatigue and improve energy levels.
• Rhodiola Rosea. Another adaptogenic herb known for its ability to reduce fatigue.
• Quality Sleep. Adequate and restful sleep is crucial for combating fatigue.

The reports  provided on Tiiips website are for informational purposes only and should not replace medical advice. Always consult a healthcare professional before making health-related decisions.

Components that can contribute to or exacerbate fatigue include various factors that can increase the sense of tiredness. Here are some examples

• Lack of Sleep. Inadequate sleep can lead to fatigue and tiredness.
• Poor Diet. A diet lacking in essential nutrients can cause fatigue.
• Dehydration. Lack of adequate hydration can lead to fatigue and tiredness.
• Excess Caffeine. High consumption of caffeine can disrupt sleep and lead to fatigue.
• Stress. Chronic stress can deplete energy and cause fatigue.
• Alcohol. Alcohol can negatively affect sleep quality and increase tiredness.
• Sedentary Lifestyle. Lack of physical exercise can contribute to fatigue.
• Medications. Some medications can have side effects that include tiredness.
• Iron Deficiency and Other Vitamins. Deficiencies in iron, vitamin D, vitamin B12, and other vitamins can cause fatigue.

References_____________________________________________________________________

(1) Barbagallo M, Veronese N, Dominguez LJ. Magnesium in Aging, Health and Diseases. Nutrients. 2021 Jan 30;13(2):463. doi: 10.3390/nu13020463. PMID: 33573164; PMCID: PMC7912123.

Abstract. Several changes of magnesium (Mg) metabolism have been reported with aging, including diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting. Mild Mg deficits are generally asymptomatic and clinical signs are usually non-specific or absent. Asthenia, sleep disorders, hyperemotionality, and cognitive disorders are common in the elderly with mild Mg deficit, and may be often confused with age-related symptoms. Chronic Mg deficits increase the production of free radicals which have been implicated in the development of several chronic age-related disorders. Numerous human diseases have been associated with Mg deficits, including cardiovascular diseases, hypertension and stroke, cardio-metabolic syndrome and type 2 diabetes mellitus, airways constrictive syndromes and asthma, depression, stress-related conditions and psychiatric disorders, Alzheimer's disease (AD) and other dementia syndromes, muscular diseases (muscle pain, chronic fatigue, and fibromyalgia), bone fragility, and cancer. Dietary Mg and/or Mg consumed in drinking water (generally more bioavailable than Mg contained in food) or in alternative Mg supplements should be taken into consideration in the correction of Mg deficits. Maintaining an optimal Mg balance all through life may help in the prevention of oxidative stress and chronic conditions associated with aging. This needs to be demonstrated by future studies.

(2) Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, Sentañes RS, Alegre-Martin J. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021 Jul 30;13(8):2658. doi: 10.3390/nu13082658. 

Abstract. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystem, and profoundly debilitating neuroimmune disease, probably of post-viral multifactorial etiology. Unfortunately, no accurate diagnostic or laboratory tests have been established, nor are any universally effective approved drugs currently available for its treatment. This study aimed to examine whether oral coenzyme Q10 and NADH (reduced form of nicotinamide adenine dinucleotide) co-supplementation could improve perceived fatigue, unrefreshing sleep, and health-related quality of life in ME/CFS patients. A 12-week prospective, randomized, double-blind, placebo-controlled trial was conducted in 207 patients with ME/CFS, who were randomly allocated to one of two groups to receive either 200 mg of CoQ10 and 20 mg of NADH (n = 104) or matching placebo (n = 103) once daily. Endpoints were simultaneously evaluated at baseline, and then reassessed at 4- and 8-week treatment visits and four weeks after treatment cessation, using validated patient-reported outcome measures. A significant reduction in cognitive fatigue perception and overall FIS-40 score (p < 0.001 and p = 0.022, respectively) and an improvement in HRQoL (health-related quality of life (SF-36)) (p < 0.05) from baseline were observed within the experimental group over time. Statistically significant differences were also shown for sleep duration at 4 weeks and habitual sleep efficiency at 8 weeks in follow-up visits from baseline within the experimental group (p = 0.018 and p = 0.038, respectively). Overall, these findings support the use of CoQ10 plus NADH supplementation as a potentially safe therapeutic option for reducing perceived cognitive fatigue and improving the health-related quality of life in ME/CFS patients. Future interventions are needed to corroborate these clinical benefits and also explore the underlying pathomechanisms of CoQ10 and NADH administration in ME/CFS.