Amyl Cinnamal is a fragrance that could be associated with sensitizing mechanisms and/or allergic reactions (1). Together with 7 other perfume components, Amyl cinnamal is considered an excellent scr ...

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Amyl Cinnamal is a fragrance that could be associated with sensitizing mechanisms and/or allergic reactions (1).

Together with 7 other perfume components, Amyl cinnamal is considered an excellent screening agent for contact allergies to perfumes (2).

Regarding the sensitization induced on the skin by fragrances, some non-reactive compounds such as α-isomethyl ionone, benzyl alcohol, amyl cinnamal and farnesol have become reactive after photo-oxidative degradation (3).

In this study an ex vivo comparison of the sensitization potency of different fragrances including Amyl cinnamal which achieved a moderate result (4).

References_____________________________

(1) Hazardous substances in frequently used professional cleaning products  Fabian Melchior Gerster, David Vernez, Pascal Pierre Wild, Nancy Brenna Hopf  Int J Occup Environ Health. 2014 Mar

(2) Contact-Allergic Reactions to Cosmetics  An Goossens  J Allergy (Cairo) 2011

(3) Chemical stability and in chemico reactivity of 24 fragrance ingredients of concern for skin sensitization risk assessment.  Avonto C, Wang M, Chittiboyina AG, Vukmanovic S, Khan IA.  Toxicol In Vitro. 2018 Feb;46:237-245. doi: 10.1016/j.tiv.2017.09.007. 

(4) Allergenicity evaluation of fragrance mix and its ingredients by using ex vivo local lymph node assay-BrdU endpoints.  Ulker OC, Kaymak Y, Karakaya A.  Food Chem Toxicol. 2014 Mar;65:162-7. doi: 10.1016/j.fct.2013.12.036.

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