Compendium of the most significant studies with reference to properties, intake, effects.

Liu L, Yuan Y, Tao J. Flavonoid-Rich Extract of Paeonia lactiflora Petals Alleviate d-Galactose-Induced Oxidative Stress and Restore Gut Microbiota in ICR Mice. Antioxidants (Basel). 2021 Nov 26;10(12):1889. doi: 10.3390/antiox10121889.

Abstract. This study was aimed to investigate the antioxidant effect of Paeonia lactiflora Pall. petal flavonoids extract (PPF) on d-galactose (d-gal)-induced ICR mice. 

Kim MJ, Kang HH, Seo YJ, Kim KM, Kim YJ, Jung SK. Paeonia lactiflora Root Extract and Its Components Reduce Biomarkers of Early Atherosclerosis via Anti-Inflammatory and Antioxidant Effects In Vitro and In Vivo. Antioxidants (Basel). 2021 Sep 23;10(10):1507. doi: 10.3390/antiox10101507.

Abstract. Although various physiological activities of compounds obtained from Paeonia lactiflora have been reported, the effects of P. lactiflora extract (PLE) on early atherosclerosis remain unclear. Therefore, in this study, we investigated the in vitro and in vivo antiatherosclerosis and in vitro antioxidant effects of PLE and its compounds. 

Chen YF, Wu KJ, Wood WG. Paeonia lactiflora Extract Attenuating Cerebral Ischemia and Arterial Intimal Hyperplasia Is Mediated by Paeoniflorin via Modulation of VSMC Migration and Ras/MEK/ERK Signaling Pathway. Evid Based Complement Alternat Med. 2013;2013:482428. doi: 10.1155/2013/482428.

Abstract. The objective of this study was to determine if Paeonia lactiflora would be protective in rodent models of cerebral ischemia and arterial intimal hyperplasia.

Kwon DA, Kim YS, Kim SK, Baek SH, Kim HK, Lee HS. Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora. Pharm Biol. 2021 Dec;59(1):391-400. doi: 10.1080/13880209.2021.1900878.

Abstract. The antifatigue effects of HemoHIM using models of citrinin and exercise-induced chronic fatigue syndrome were investigated.  HemoHIM is an herbal preparation containing Angelica gigas Nakai (Apiaceae), Cnidium officinale Makino (Umbelliferae), and Paeonia lactiflora Pallas (Paeoniaceae) developed for immune regulation.

Lee HS, Kim Y. Paeonia lactiflora Inhibits Cell Wall Synthesis and Triggers Membrane Depolarization in Candida albicans. J Microbiol Biotechnol. 2017 Feb 28;27(2):395-404. doi: 10.4014/jmb.1611.11064.

Abstract. In this study, we report on the antifungal activity of an ethanol extract from Paeonia lactiflora against Candida albicans, showing that the antifungal activity is associated with the synergistic actions of preventing cell wall synthesis, enabling membrane depolarization, and compromising permeability.

Lee M, Park JH, Gil J, Lee J, Lee Y. The complete chloroplast genome of Paeonia lactiflora Pall. (Paeoniaceae). Mitochondrial DNA B Resour. 2019 Jul 22;4(2):2715-2716. doi: 10.1080/23802359.2019.1644548.

Abstract. The complete chloroplast genome sequence of Paeonia lactiflora was obtained by de novo assembly using next-generation sequencing.