Compendium of the most significant studies with reference to properties, intake, effects.

Pedrotti E, Bonacci E, Kilian R, Pagnacco C, Fasolo A, Anastasi M, Manzini G, Bosello F, Marchini G. The Role of Topical Povidone-Iodine in the Management of Infectious Keratitis: A Pilot Study. J Clin Med. 2022 Feb 5;11(3):848. doi: 10.3390/jcm11030848.

Abstract. The aim of this prospective explorative study was to evaluate the safety and the effectiveness of topical polyvinylpyrrolidone-iodine (PVP-I) administered during the time-to-results period for pathogen identification and susceptibility testing in patients with infectious keratitis (IK). 

Kuskov AN, Luss AL, Gritskova IA, Shtilman MI, Motyakin MV, Levina II, Nechaeva AM, Sizova OY, Tsatsakis AM, Mezhuev YO. Kinetics and Mechanism of Synthesis of Carboxyl-Containing N-Vinyl-2-Pyrrolidone Telehelics for Pharmacological Use. Polymers (Basel). 2021 Aug 1;13(15):2569. doi: 10.3390/polym13152569. 

Abstract. It was found that sulfanylethanoic and 3-sulfanylpropanoic acids are effective regulators of molecular weight with chain transfer constants of 0.441 and 0.317, respectively, and show an unexpected acceleration effect on the radical polymerization of N-vinyl-2-pyrrolidone, initiated by 2,2'-azobisisobutyronitrile.  

Harrison C, Zent R, Schneck E, Flynn CE, Drees M. Infection prevention versus antimicrobial stewardship: Does nasal povidone-iodine interfere with methicillin-resistant Staphylococcus aureus (MRSA) screening? Infect Control Hosp Epidemiol. 2021 Dec 22:1-2. doi: 10.1017/ice.2021.152. 

Wade RG, Bourke G, Wormald JCR, Totty JP, Stanley GHM, Lewandowski A, Rakhra SS, Gardiner MD; CIPHUR Collaborative. Chlorhexidine versus povidone-iodine skin antisepsis before upper limb surgery (CIPHUR): an international multicentre prospective cohort study. BJS Open. 2021 Nov 9;5(6):zrab117. doi: 10.1093/bjsopen/zrab117.

Abstract. This study aimed to evaluate the safety and effectiveness of different topical antiseptics before upper limb surgery.

Buchsel PC. Polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair): a bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions. Expert Opin Drug Metab Toxicol. 2008 Nov;4(11):1449-54. doi: 10.1517/17425255.4.11.1449.

Abstract. The purpose of this paper is to review the benefit of polyvinylpyrrolidone-sodium hyaluronate gel, a topical oral mucosal barrier gel to prevent or diminish the pain of OM and other oral lesions.

D'Souza AJ, Schowen RL, Topp EM. Polyvinylpyrrolidone-drug conjugate: synthesis and release mechanism. J Control Release. 2004 Jan 8;94(1):91-100. doi: 10.1016/j.jconrel.2003.09.014. Erratum in: J Control Release. 2004 Jun 18;97(2):385.

Abstract. The approach serves as a prototype for the conjugation of other drugs with primary and secondary amine functional groups with PVP, including peptides and proteins.

Shet M, Westover J, Hong R, Igo D, Cataldo M, Bhaskar S. In vitro inactivation of SARS-CoV-2 using a povidone-iodine oral rinse. BMC Oral Health. 2022 Feb 25;22(1):47. doi: 10.1186/s12903-022-02082-9.

Abstract. This study assessed the in vitro virucidal activity of 0.5% (w/v) povidone-iodine (PVP-I) oral rinse against SARS-CoV-2 to demonstrate its utility as a professional oral rinse.

Racila AM, O'Shea AMJ, Nair R, Dukes K, Herwaldt LA, Boyken L, Diekema D, Ward MA, Cobb J, Jacob J, Pegues D, Bleasdale S, Vijayan A, Mutneja A, Fraer M, O'Connell-Moore D, Tolomeo P, Mendez M, Jaworski E, Schweizer ML. Using nasal povidone-iodine to prevent bloodstream infections and transmission of Staphylococcus aureus among haemodialysis patients: a stepped-wedge cluster randomised control trial protocol. BMJ Open. 2021 Dec 3;11(12):e048830. doi: 10.1136/bmjopen-2021-048830.

Abstract. Our objective is to determine the clinical efficacy and effectiveness of a novel intervention using nasal povidone-iodine (PVI) to prevent BSIs among patients in haemodialysis units. We will survey patients and conduct qualitative interviews with healthcare workers to identify barriers and facilitators to implementing the intervention.