Carboxymethyl cellulose is one of the viscous polymers used most often in artificial tears to prolong their permanence on the ocular surface (1). Dry eye syndrome is treated with different drop compo ...

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Carboxymethyl cellulose is one of the viscous polymers used most often in artificial tears to prolong their permanence on the ocular surface (1).

Dry eye syndrome is treated with different drop compositions, hyaluronic acid, carmellose, seawater washes. The results of this study did not detect differences between carmellose and seawater washes (2).

Carboxymethylcellulose by binding to matrix proteins stimulated the attachment of corneal-epithelial cells, migration and epithelialization of corneal wounds (3).

References______________________________

(1) Combination of hyaluronic acid, carmellose, and osmoprotectants for the treatment of dry eye disease.

Mateo Orobia AJ, Saa J, Ollero Lorenzo A, Herreras JM.

Clin Ophthalmol. 2018 Mar 6;12:453-461. doi: 10.2147/OPTH.S157853. eCollection 2018

(2) A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome.

Diaz-Llopis M, Pinazo-Duran MD, Diaz-Guiñon L, Rahhal-Ortuño M, Perez-Ramos M, Bosch R, Gallego-Pinazo R, Dolz-Marco R, Diaz-Guiñon T, Diaz M, Romero FJ, Cisneros A.

Clin Ophthalmol. 2019 Mar 12;13:483-490. doi: 10.2147/OPTH.S185409. eCollection 2019.

(3) Carboxymethylcellulose binds to human corneal epithelial cells and is a modulator of corneal epithelial wound healing.

Garrett Q, Simmons PA, Xu S, Vehige J, Zhao Z, Ehrmann K, Willcox M.

Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1559-67.

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