Compendium of the most significant studies with reference to properties, intake, effects.

Zhang Y, Yang S, Zhou W, Fu H, Qian L, Miron RJ. Addition of a Synthetically Fabricated Osteoinductive Biphasic Calcium Phosphate Bone Graft to BMP2 Improves New Bone Formation. Clin Implant Dent Relat Res. 2016 Dec;18(6):1238-1247. doi: 10.1111/cid.12384.

Abstract. The aim of the present study was to assess whether the combination of Bone morphogenetic protein-2 with this novel Biphasic Calcium Phosphate (BCP) scaffold may additionally promote new bone regeneration.

O'Shea FD, McCarthy GM. Basic calcium phosphate deposition in the joint: a potential therapeutic target in osteoarthritis. Curr Opin Rheumatol. 2004 May;16(3):273-8. doi: 10.1097/00002281-200405000-00018. 

Abstract. Basic calcium phosphate crystals are responsible for a number of clinical syndromes. The study of basic calcium phosphate crystal deposition diseases has been hindered by a lack of readily available, accurate, diagnostic tests. Recent data have provided further understanding of the mechanisms by which basic calcium phosphate crystals induce inflammation and degeneration within the joint, as well as their potential role in other conditions such as cancer and atherosclerosis.

van Houdt CI, Preethanath RS, van Oirschot BA, Zwarts PH, Ulrich DJ, Anil S, Jansen JA, van den Beucken JJ. Toward accelerated bone regeneration by altering poly(D,L-lactic-co-glycolic) acid porogen content in calcium phosphate cement. J Biomed Mater Res A. 2016 Feb;104(2):483-92. doi: 10.1002/jbm.a.35584.

Abstract. This work aimed to compare in vitro degradation of dense PLGA microspheres and milled PLGA particles as porogens within CPC, considering that the manufacturing of milled PLGA is more cost-effective when compared with PLGA microspheres.

Kanzaki N, Treboux G, Onuma K, Tsutsumi S, Ito A. Calcium phosphate clusters. Biomaterials. 2001 Nov;22(21):2921-9. doi: 10.1016/s0142-9612(01)00039-4. 

Abstract. The potential energy surfaces associated with [Ca3(PO4)2n clusters are analyzed in detail using ab initio calculations for n ranging from one to four. Considering separated clusters, energy criteria favor the so-called Posner's cluster Ca9(PO4)6, which is the core of the actual structural model of amorphous calcium phosphate. This is rationalized through the existence of a distinct CaO bonding pattern in this cluster. Considering aggregated clusters as a possible model for amorphous calcium phosphate, the aggregation of Ca3(PO4)2 clusters appears as an alternative to Posner's hypothesis.

Suarez GMG, Merino-Ribas A, Haro MC, Freiría XB, Alemany NM, Bover B, Mendez IG, Paez CN, Devia CMC, Teran MP, Escuder PT, Martinez JC. Multi-organ involvement and intratubular calcium phosphate deposition in the kidney biopsy: what should we investigate? Eat Weight Disord. 2022 May 12. doi: 10.1007/s40519-022-01406-6. 

Abstract. Anorexia nervosa is frequently associated with alcohol use disorder. Both of them may adversely affect almost every body system, leading to worse clinical outcomes and high mortality risk. Nonetheless, there is little evidence interrelating anorexia nervosa, alcohol use disorder, and kidney failure.

Seifert A, Tylek T, Blum C, Hemmelmann N, Böttcher B, Gbureck U, Groll J. Calcium phosphate-based biomaterials trigger human macrophages to release extracellular traps. Biomaterials. 2022 Apr 23;285:121521. doi: 10.1016/j.biomaterials.2022.121521. 

Abstract. In this study, the response of human monocyte-derived macrophages in vitro to two different CaPs (α-tricalcium phosphate (α-TCP) and calcium deficient hydroxyapatite (CDHA)) as well as different pore structures was investigated.

Sebastian R, Paul ST, Azher U, Reddy D. Comparison of Remineralization Potential of Casein Phosphopeptide: Amorphous Calcium Phosphate, Nano-hydroxyapatite and Calcium Sucrose Phosphate on Artificial Enamel Lesions: An In Vitro Study. Int J Clin Pediatr Dent. 2022 Jan-Feb;15(1):69-73. doi: 10.5005/jp-journals-10005-2339.

Abstract. To evaluate and compare the remineralization potential of CPP-ACP, nano-hydroxyapatite, and calcium sucrose phosphate toothpaste on artificial enamel caries lesions by means of microhardness testing.

Yoshikawa Y, Tamura A, Tsuda S, Domae E, Zhang S, Yui N, Ikeo T, Yoshizawa T. Calcium phosphate-adsorbable and acid-degradable carboxylated polyrotaxane consisting of β-cyclodextrins suppresses osteoclast resorptive activity. Dent Mater J. 2022 May 19. doi: 10.4012/dmj.2021-331. 

Abstract. In this study, we investigated whether carboxymethyl carbamate-modified AdPRX (CMC-AdPRX) can be used for adsorption to calcium phosphate to treat bone diseases. 

Zakowiecki D, Hess T, Cal K, Mikolaszek B, Garbacz G, Haznar-Garbacz D. Directly compressible formulation of immediate release rosuvastatin calcium tablets stabilized with tribasic calcium phosphate. Pharm Dev Technol. 2022 May 8:1-10. doi: 10.1080/10837450.2022.2073370.

Abstract.  In the present study, a special grade of tribasic calcium phosphate excipient was used to chemically stabilize RSC in a directly compressible immediate release tablet formulation.

Köse N, Asfuroğlu ZM, Köse A, Şahintürk V, Gürbüz M, Doğan A. Silver ion-doped calcium phosphate-based bone-graft substitute eliminates chronic osteomyelitis: An experimental study in animals. J Orthop Res. 2021 Jul;39(7):1390-1401. doi: 10.1002/jor.24946.

Abstract. Despite the latest technologies and advances in microbiology and orthopedic surgery, chronic osteomyelitis is still a challenging disorder. Antibiotic resistance and bacterially induced bone destruction can have very serious consequences. We hypothesized that calcium phosphate-based bone graft substitution with silver ion doping would simultaneously treat bone infection and the bony defect in the chronic osteomyelitis.