Spermidine is a very interesting and particular polycation and polyamine that participates in a series of biological procedures, some of which are known and still unknown. It can be said generic ...

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Spermidine is a very interesting and particular polycation and polyamine that participates in a series of biological procedures, some of which are known and still unknown.

It can be said generically that this particle prolongs the life of various organisms, including the common yeast (Saccharomyces cerevisiae), some nematode insects (Caenorhabditis elegans) and flies (Drosophila melanogaster). In laboratory tests in rats, it significantly reduces the oxidative damage that leads to aging.

This particle can act as a universal anti-aging drug (1) and combats old-age diseases such as Parkinson's and memory loss (2).

It also reduces the loss of locomotor activity related to age (3).

In the scalp it prolongs and regulates the functions of human epithelial stem cells in hair follicles (4).

It contributes, with its anti-inflammatory characteristics to protect the colon and in this study that refers to feminine subjects, it has been noted a utility for the health of the colon (5).

Molecular formula: C₇H₁₉N₃

Molecular weight: 145.25

CAS: 124-20-9

Manufacturers: Sigma Aldrich

Synonyms: 1,8-Diamino-4-azaoctane, N- (3-Aminopropyl) -1,4-diaminobutane

 

References________________________________________

(1) Autophagy. 2010 Jan;6(1):160-2.
Spermidine: a novel autophagy inducer and longevity elixir.
Madeo F1, Eisenberg T, Büttner S, Ruckenstuhl C, Kroemer G.

Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review.
Minois N.
Gerontology. 2014;60(4):319-26. doi: 10.1159/000356748.  

(2) Spermidine protects against α-synuclein neurotoxicity.
Büttner S, Broeskamp F, Sommer C, Markaki M, Habernig L, Alavian-Ghavanini A, Carmona-Gutierrez D, Eisenberg T, Michael E, Kroemer G, Tavernarakis N, Sigrist SJ, Madeo F.
Cell Cycle. 2014;13(24):3903-8. doi: 10.4161/15384101.2014.973309.

Spermidine-triggered autophagy ameliorates memory during aging.
Sigrist SJ, Carmona-Gutierrez D, Gupta VK, Bhukel A, Mertel S, Eisenberg T, Madeo F.
Autophagy. 2014 Jan;10(1):178-9. doi: 10.4161/auto.26918.   

(3) Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
Minois N, Rockenfeller P, Smith TK, Carmona-Gutierrez D.
PLoS One. 2014 Jul 10;9(7):e102435. doi: 10.1371/journal.pone.0102435. 

(4) N(1)-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles.
Ramot Y, Marzani B, Pinto D, Kloepper JE, Paus R.
Arch Dermatol Res. 2015 Nov;307(9):841-7. doi: 10.1007/s00403-015-1592-9.

Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions.
Ramot Y, Tiede S, Bíró T, Abu Bakar MH, Sugawara K, Philpott MP, Harrison W, Pietilä M, Paus R.
PLoS One. 2011;6(7):e22564. doi: 10.1371/journal.pone.0022564. 

(5) Am J Clin Nutr. 2015 Aug;102(2):411-9. doi: 10.3945/ajcn.114.103895.
Dietary polyamine intake and colorectal cancer risk in postmenopausal women.
Vargas AJ1, Ashbeck EL2, Wertheim BC2, Wallace RB3, Neuhouser ML4, Thomson CA5, Thompson PA6

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