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 | "Antitumorigenic and antipromoting activities" by Kevin-Wooderly (155 pt) | 2016-Jan-05 19:54 |
Sanguiin H6 is found in fruits. Tannin from Sanguisorba officinalis (burnet bloodwort), Rubus fruticosus (blackberry) and Rubus idaeus (raspberry) Sanguiin h6 belongs to the family of Biflavonoids and Polyflavonoids. These are organic compounds containing at least two flavan derivatives. www.hmdb.ca/metabolites/HMDB29526
Ellagic acid (EA) was inhibiting lung tumorigenesis induced by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice. In the present study, we observed that the inhibition of lung tumorigenesis was independent of the solvent used to purified EA. Pomegranate peels extract containing punicalagin (alpha and beta anomers) (10 g/kg diet) and oligomeric anthocyanins (6 g/kg diet) did not inhibit lung tumorigenesis. Raspberry extract (2x15 mg) containing sanguiin H6 and lambertianin D as well as oligomeric procyanidins (2x15 mg) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity by about 30%. The same treatments inhibit TPA-stimulated hydroperoxide (HPx) production by about 30 and 70%. Raspberry ellagitannins and oligomeric procyanidins respectively inhibit TPA stimulated DNA synthesis by 42 and 26%. Our results su est that hydrolyzable and condensed tannins from various sources, which can inhibit the ODC, HPx, and DNA responses to TPA, might also inhibit the tumor-promoting activity of this agent. The results of this study show that EA and ellagitannins have different antitumorigenic and antipromoting activities. Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin.
Castonguay A1, Gali H, Perchellet E, Gao X, Boukharta M, Jalbert G, Okuda T, Yoshida T, Hatano T, Perchellet J.
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