The term "corn syrup" is usually found in the ingredients of baked goods and beverages, in the food field, and is a rather unusual term as it does not specify whether the content is fructose, glucose ...

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The term "corn syrup" is usually found in the ingredients of baked goods and beverages, in the food field, and is a rather unusual term as it does not specify whether the content is fructose, glucose or both.
Corn syrup contains, in any case, a high percentage of fructose, a component rather discussed from a healthy point of view because it has numerous contraindications including, for example, intolerance which can also be hereditary (1).

Above all, the increasing spread of fructose consumption in beverages, has brought the attention of researchers to the risks that the intake of this ingredient has for health. Especially in young people, the association between the consumption of sugary drinks containing a high fructose content is associated with a risk of obesity (2), fatty liver disease (3).

There is a link between joint and gut inflammation of unknown etiology in arthritis. Existing research indicates that regular consumption of high-fructose corn syrup sweetened (HFCS) soft drinks, but not diet soft drinks, may be associated with increased risk of seropositive rheumatoid arthritis (RA) in women, independent of other dietary and lifestyle factors. One unexplored hypothesis for this association is that fructose malabsorption, due to regular consumption of excess free fructose (EFF) and HFCS, contributes to fructose reactivity in the gastrointestinal tract and intestinal in situ formation of enFruAGEs, which once absorbed, travel beyond the intestinal boundaries to other tissues and promote inflammation. In separate studies, the accumulation of advanced glycation end-products has been associated with joint inflammation in RA. Objective of this study was to assess the association between EFF beverages intake and non-age, non-wear and tear-associated arthritis in US young adults. Excess free fructose beverage intake is significantly associated with arthritis in US adults aged 20-30 years, possibly due to the intestinal in situ formation of enFruAGEs (4).

Corn syrup studies

References________________________________

(1) Hereditary Fructose Intolerance.
Baker P II, Ayres L, Gaughan S, Weisfeld-Adams J.
In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Mefford HC, Smith RJH, Stephens K, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2016.   2015 Dec 17. 

(2) Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance.
Lin WT, Chan TF, Huang HL, Lee CY, Tsai S, Wu PW, Yang YC, Wang TN, Lee CH.
J Pediatr. 2016 Apr;171:90-96.e1. doi: 10.1016/j.jpeds.2015.12.061.

(3) Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease.
Softic S, Cohen DE, Kahn CR.
Dig Dis Sci. 2016 May;61(5):1282-93. doi: 10.1007/s10620-016-4054-0. 

(4) Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20-30 years.
DeChristopher LR, Uribarri J, Tucker KL.
Nutr Diabetes. 2016 Mar 7;6:e199. doi: 10.1038/nutd.2016.7.

 

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