Compendium of the most significant studies with reference to properties, intake, effects.

Thoorens G, Krier F, Leclercq B, Carlin B, Evrard B. Microcrystalline cellulose, a direct compression binder in a quality by design environment--a review. Int J Pharm. 2014 Oct 1;473(1-2):64-72. doi: 10.1016/j.ijpharm.2014.06.055.

Abstract. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes.

Santos JMD, Ignácio EO, Bis-Souza CV, Silva-Barretto ACD. Performance of reduced fat-reduced salt fermented sausage with added microcrystalline cellulose, resistant starch and oat fiber using the simplex design. Meat Sci. 2021 May;175:108433. doi: 10.1016/j.meatsci.2021.108433.

Abstract.  The aim of this study was to evaluate fermented sausages with simultaneous reduction of fat (25%) and salt (25% KCl; 75% NaCl) using up to 2% of three different dietary fiber: microcrystalline cellulose (MCC), resistant starch (RS) and oat fiber (OF). Technological and sensory evaluations used the simplex-centroid mixture design.

Butler DC, Presnell SE, Bruner E, Page T, Cuff R, Phillips A. Microcrystalline Cellulose and Crospovidone Identified in Placentas With Vaginal Misoprostol Use. Am J Forensic Med Pathol. 2020 Sep;41(3):176-181. doi: 10.1097/PAF.0000000000000557.

Abstract. Microcrystalline cellulose and/or crospovidone was identified in 0 (0%) of 88 cases with no vaginal administration or low-dose vaginal administration and 29 (66%) of 44 placentas with high-dose vaginal administration. When identified, microcrystalline cellulose and/or crospovidone is most commonly present on the maternal surfaces of the extraplacental membranes.

Żelaziński T. Properties of Biocomposites from Rapeseed Meal, Fruit Pomace and Microcrystalline Cellulose Made by Press Pressing: Mechanical and Physicochemical Characteristics. Materials (Basel). 2021 Feb 13;14(4):890. doi: 10.3390/ma14040890.

Abstract. This paper presents the results of research on biocomposites made of the mixture of post-extraction rapeseed meal, microcrystalline cellulose and various fruit pomace (chokeberry, blackcurrant, apple and raspberry pomace). The biocomposites were made in the process of mechanical thickening by means of a heated mould (die and stamp) which is located between two heating elements installed on a hydraulic press. 

Casanova F, Pereira CF, Ribeiro AB, Freixo R, Costa E, E Pintado M, Fernandes JC, Ramos ÓL. Novel Micro- and Nanocellulose-Based Delivery Systems for Liposoluble Compounds. Nanomaterials (Basel). 2021 Oct 1;11(10):2593. doi: 10.3390/nano11102593.

Abstract. In this context, this review describes the fast-growing field of micro- and nanocellulose based delivery systems with a focus on the release of liposoluble bioactive compounds. The state of research on this field is reviewed in this article, which also covers the chemistry, preparation, properties, and applications of micro- and nanocellulose based delivery systems.

Alekseeva OV, Shibaeva VD, Noskov AV, Ivanov VK, Agafonov AV. Enhancing the Thermal Stability of Ionogels: Synthesis and Properties of Triple Ionic Liquid/Halloysite/MCC Ionogels. Molecules. 2021 Oct 14;26(20):6198. doi: 10.3390/molecules26206198.

Abstract.  In this study, an ionic liquid (IL), 1-butyl-3-methylimidazolium acetate, was used to prepare ionogels with microcrystalline cellulose (MCC) and halloysite (Hal). SEM, XRD, TG, DSC, FTIR spectroscopy, conductometry and mechanical tests were used to study the morphology, structure, thermal behaviour and electrophysical and mechanical characteristics of synthesised ionogels.

Portier C, Vigh T, Di Pretoro G, Leys J, Klingeleers D, De Beer T, Vervaet C, Vanhoorne V. Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying - A QbD approach. Int J Pharm X. 2021 Mar 19;3:100077. doi: 10.1016/j.ijpx.2021.100077.

Abstract. This study assessed the impact of microcrystalline cellulose (MCC) batch-to-batch variability and process settings in a continuous twin screw wet granulation and semi-continuous drying line.

Klinger J, Daniels R. Assessing a Mass-Based Method for the Preparation of Low-Dosed Paediatric Capsules with Baclofen and Spironolactone. Pharmacy (Basel). 2021 Mar 8;9(1):56. doi: 10.3390/pharmacy9010056.

Abstract. The hard capsules were prepared using three different bulking agents consisting of either mannitol, lactose-monohydrate and microcrystalline cellulose mixed with 0.5% colloidal silica.