Diazolidinyl urea is a chemical compound, a preservative used in industry and cosmetics.

The name describes the structure of the molecule.

• Diazolidinyl indicates the presence of a diazolidine ring structure, which is a type of cyclic compound.
• urea refers to the presence of the urea functional group, which consists of a carbonyl (C=O) bonded to two amine (-NH2) groups.

Function of the Components

Diazolidinyl urea is commonly used as a preservative in cosmetics and personal care products. It works by releasing formaldehyde, which prevents the growth of bacteria and other microorganisms.

Raw Materials Used in Production.

• Allantoin: A compound derived from uric acid.
• Formaldehyde: A volatile organic compound.
• Urea: An organic compound produced from protein degradation.

Step-by-step Summary of Industrial Production Process.

• Preparation of Urea and Allantoin. Both are purified and readied for reaction.
• Condensation. Allantoin and urea undergo a condensation reaction in the presence of formaldehyde.
• Purification. Removal of impurities through various purification processes.
• Neutralization. The product might be neutralized if required.

Form and Color.

Diazolidinyl urea appears as a white to slightly yellowish powder.

This substance is used in the following products:

Cosmetic Industry. Used as a preservative in a wide range of cosmetic products, such as creams, lotions, shampoos, and makeup products.

Antibacterial and Antifungal Properties. It helps prevent the growth of bacteria and fungi in products, extending their shelf life.

Skincare Products. Found in moisturizers, toners, serums, and other skincare items.

• pH regulators
• water treatment products
• laboratory chemicals
• washing & cleaning products.
• formulation of industrial mixtures
• fillers
• putties
• plasters
• modelling clay 

Diazolidinyl urea studies

Molecular Formula: C₈H₁₄N₄O₇

Molecular Weight: 278.221 g/mol

UNII: H5RIZ3MPW4

CAS: 78491-02-8

EC Number: 278-928-2

PubChem Substance ID 57654106

MDL number MFCD03547942

Synonyms:

• 1-(1,3-Bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-1,3-bis(hydroxymethyl)urea
• Imidazolidinyl urea 11
• N-(1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-
• Urea, N-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)-
• Urea, N-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl-N,N'-bis(hyd- roxymethyl)-
• N-[1,3-bis(hydroxymethyl)-2,5-dioxo(1,3-diazolidin-4-yl)]-N-(hydroxymethyl)[(h ydroxymethyl)amino]carboxamide
• N,N'-Bis(hydroxymethyl) urea
• DSSTox_CID_9559
• 1-[1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea
• DSSTox_RID_78776
• N-(1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)urea
• N-(Hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N'-(hydroxymethyl) urea
• N-(Hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N'-(hydroxymethyl)urea
• n-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-n,n'-bis(hydroxymethyl)urea
• Urea, N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)-
• DSSTox_GSID_29559
• W-104279
• Germall II
• Germall 11
• CHEMBL3187032
• DTXSID0029559
• CHEBI:136014
• Tox21_202068
• Tox21_303365
• AC1L1WT2
• AC1Q7DD1
• SCHEMBL34370
• AC1Q6F57
• SBB003028
• AKOS016010254
• CHM0029140
• MCULE-9508067464
• 5-(1,3-bis(hydroxymethyl)ureido)-1,3-bis(hydroxymethyl)imidazol-2,5(3H,5H)dione
• KS-0000093H
• NCGC00249159-01
• NCGC00257237-01
• NCGC00259617-01
• AK115000
• AN-36631
• O201
• ST056226
• SY033470
• AX8124122
• LS-159067
• D3769
• FT-0641680
• ST24026808

References_________________________________________________________________________

(1)  Jackson EM. Formalehyde in personal care products.  Jackson EM.  Skin Pharmacol Physiol. 2012;25(5):236-40. doi: 10.1159/000338429. Epub 2012 Jun 13.

(2) Carbajo JB, Perdigón-Melón JA, Petre AL, Rosal R, Letón P, García-Calvo E. Personal care product preservatives: risk assessment and mixture toxicities with an industrial wastewater.  Water Res. 2015 Apr 1;72:174-85. doi: 10.1016/j.watres.2014.12.040.