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 | "Diazolidinyl urea studies" by AColumn (9309 pt) | 2020-Oct-07 21:06 |
| Evaluation | N. Experts | Evaluation | N. Experts |
|---|---|---|---|
| 1 | 6 | ||
| 2 | 7 | ||
| 3 | 8 | ||
| 4 | 9 | ||
| 5 | 10 |
The most important studies on.
On Diazolidinyl urea there is a great deal of scientific literature in believing this component, which releases formaldehyde, an allergen, ie it can give contact allergies (1).
The frequency of allergies was studied in 405 patients (2).
Another study analyzed the allergic reactions of 45,000 subjects (3).
Diazolidinyl urea, when administered in the conjunctival sac of albino rabbits at a concentration of 5% (unspecified solvent), has been reported to be irritating to ocular tissues for a period of seven days, without rinsing with water (4).
The aquatic toxicity of eight preservatives often used in personal care products (Iodopropynyl butylcarbamate, Bronopol, Diazolidinyl urea, benzalkonium chloride, zinc pyrithione, propylparaben, triclosan and a mixture of methylchloroisothiazolinone and methylchloroisotholinone) has been evaluated . The examined preservatives showed considerable toxicity in the studied biological assays (5).
Other studies
Topical therapeutic corneal and scleral tissue cross-linking solutions: in vitro formaldehyde release studies using cosmetic preservatives.
Takaoka A, Cao K, Oste EM, Nagasaki T, Paik DC.
Biosci Rep. 2019 May 3;39(5). pii: BSR20182392. doi: 10.1042/BSR20182392. Print 2019 May 31
Effects of Several Cosmetic Preservatives on ROS-Dependent Apoptosis of Rat Neural Progenitor Cells.
Ryu O, Park BK, Bang M, Cho KS, Lee SH, Gonzales ELT, Yang SM, Kim S, Eun PH, Lee JY, Kim KB, Shin CY, Kwon KJ.
Biomol Ther (Seoul). 2018 Nov 1;26(6):608-615. doi: 10.4062/biomolther.2017.221.
An insight into toxicity and human-health-related adverse consequences of cosmeceuticals - A review.
Bilal M, Iqbal HMN.
Sci Total Environ. 2019 Jun 20;670:555-568. doi: 10.1016/j.scitotenv.2019.03.261.
References_________________________________________________
(1) The Spanish standard patch test series: 2016 update by the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC).
Hervella-Garcés M, García-Gavín J, Silvestre-Salvador JF; en representación del Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC). Actas Dermosifiliogr. 2016 Sep;107(7):559-66. doi: 10.1016/j.ad.2016.04.009
(2) Preservatives as important etiologic factors of allergic contact dermatitis.
Kręcisz B, Chomiczewska-Skóra D, Kieć-Świerczyńska M. Med Pr. 2015;66(3):327-32. doi: 10.13075/mp.5893.00176.
(3) Human Cumulative Irritation Tests of Common Preservatives Used in Personal Care Products: A Retrospective Analysis of Over 45 000 Subjects.
Walters RM, Khanna P, Hamilton M, Mays DA, Telofski L. Toxicol Sci. 2015 Nov;148(1):101-7. doi: 10.1093/toxsci/kfv158.
(4) Final report on the safety assessment of diazolidinyl urea. Int J Toxicol. 1990; 9: 229–245.
(5) Personal care product preservatives: risk assessment and mixture toxicities with an industrial wastewater.
Carbajo JB, Perdigón-Melón JA, Petre AL, Rosal R, Letón P, García-Calvo E.
Water Res. 2015 Apr 1;72:174-85. doi: 10.1016/j.watres.2014.12.040.
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