By the term Copper complexes of the chlorophylls, a semisynthetic mixture of the water-soluble sodium salt of the copper chlorophyllin, is indicated and small analogous molecules derived from the chlorophyll plant possessing a unique combination of anti-inflammatory, antibacterial and antioxidant activities (1).

Chlorophyll copper complexes have been used topically for many years to aid wound healing (2), but have also shown inhibition of hyaluronidase activity in vitro, supporting the notion that topical application of this component may be a useful approach for improve the appearance of facial skin (3). This clinical study demonstrates a statistically significant improvement in the repair of photo-aged skin from topical treatment with a test formulation containing a 0.05% liposomal dispersion of chlorophyll complexes (4).

References_______________________________________________________________________

(1) Tumolo T, Lanfer-Marquez UM.Tumolo, T., & Lanfer-Marquez, U. M. (2012). Copper chlorophyllin: A food colorant with bioactive properties?. Food Research International, 46(2), 451-459. Copper chlorophyllin: a food colorant with bioactive properties? Food Res Int. 2012

(2) Smith, R. G. (2008). Enzymatic debriding agents: an evaluation of the medical literature. Ostomy Wound Manage, 54(8), 16-34.

(3) McCook JP, Dorogi PL, Vasily DB, Cefalo DR. In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs. Clin Cosmet Investig Dermatol. 2015

(4) McCook JP, Stephens TJ, Jiang LI, Law RM, Gotz V. Ability of sodium copper chlorophyllin complex to repair photoaged skin by stimulation of biomarkers in human extracellular matrix. Clin Cosmet Investig Dermatol. 2016 Jul 25;9:167-74. doi: 10.2147/CCID.S111139. PMID: 27524916; PMCID: PMC4966572.