The preserving agents that determine the shelf life of cosmetic products must have effective antimicrobial activity in compliance with safety requirements for topical use. Antimicrobial susceptibility ...

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The preserving agents that determine the shelf life of cosmetic products must have effective antimicrobial activity in compliance with safety requirements for topical use. Antimicrobial susceptibility tests showed that 1,2-hexanediol exhibited a broad spectrum activity against Gram-positive and Gram-negative bacteria with MIC of 0 · 5-2% (v / v) (1).

 
Regarding safety, type IV skin hypersensitivity reactions to 1,2-hexanediol (2) have not been observed.

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Dermal peptide delivery using enhancer molecules and colloidal carrier systems - part V#: Influence of enhancers on the permeation of PKEK through snake skin.  Foerster A, Neubert RHH.  Pharmazie. 2019 Mar 1;74(3):136-141. doi: 10.1691/ph.2019.8105.

Phototoxicity and chronic toxicity of methyl paraben and 1,2-hexanediol in Daphnia magna.  Lee J, Park N, Kho Y, Lee K, Ji K.  Ecotoxicology. 2017 Jan;26(1):81-89. doi: 10.1007/s10646-016-1743-6.
 
References__________________________________

(1) Food-grade antimicrobials potentiate the antibacterial activity of 1,2-hexanediol.
Yogiara, Hwang SJ, Park S, Hwang JK, Pan JG.
Lett Appl Microbiol. 2015 May;60(5):431-9. doi: 10.1111/lam.12398.
(2) Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol.
Levy SB, Dulichan AM, Helman M.
Cutan Ocul Toxicol. 2009;28(1):23-4. doi: 10.1080/15569520802636082.

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