DMDM hydantoin is used as a bactericide and preservative in many cosmetic products, but it is a component registered in the FAR register of "releasers formaldehyde", ie of those chemical products that ...

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DMDM hydantoin is used as a bactericide and preservative in many cosmetic products, but it is a component registered in the FAR register of "releasers formaldehyde", ie of those chemical products that release formaldehyde. Regarding toxicity, the level was ascertained from 0.001 to 0.1 mM on human skin (1).

On a sample of 4,238 patients tested with the patch-test, positive allergic reactions for DMDM Hydantoin were 1.6% (2):

• Formaldehyde 6.6%
• Quaternium-15 6.4%
• Methylchloroisothiazolinone / methylisothiazolinone 5%
• Lanolin alcohol 4.6%
• Cinnamic aldehyde 3.9%
• Diazolidinyl urea 2.1%
• Imidazolidinyl urea 1.6%
• Bronopol 1.6%
• Glutaral 1.5%
• Parabens mixed 1.4%

References______________________________

(1) Cosmetic preservatives as therapeutic corneal and scleral tissue cross-linking agents.
Babar N, Kim M, Cao K, Shimizu Y, Kim SY, Takaoka A, Trokel SL, Paik DC.
nvest Ophthalmol Vis Sci. 2015 Jan 29;56(2):1274-82. doi: 10.1167/iovs.14-16035.
(2) North American contact dermatitis group patch test results: 2011-2012.
Warshaw EM, Maibach HI, Taylor JS, Sasseville D, DeKoven JG, Zirwas MJ, Fransway AF, Mathias CG, Zug KA, DeLeo VA, Fowler JF Jr, Marks JG, Pratt MD, Storrs FJ, Belsito DV.
Dermatitis. 2015 Jan-Feb;26(1):49-59. doi: 10.1097/DER.0000000000000097.

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