Hexapeptide-47 is a chemical compound, a synthetic protein composed of amino acids joined together including: glycine, histidine, proline, serine, and tryptophan. and is used in anti-aging cosmetic products.

It is an abbreviated class of biomolecules and produced by chemical or enzymatic hydrolysis

Peptides are natural products, protein fragments, consisting of at least two amino acids and have the ability to regulate some physiological processes: immunity, defense, growth, reproduction. In dermatology and cosmetics their use concerns the correct development of pigmentation, inflammation and as signal modulators of the extracellular matrix component. 

What it is used for and where

Cosmetics - INCI Functions

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

Studies

Fish are a relatively recent source of bioactive peptides and proteins used by the pharmaceutical and cosmetic industries for the anti-aging, antimicrobial and antioxidant properties of the active ingredients. Peptides derived from the marine environment year a broad spectrum of bioactivities: antioxidant, antimicrobial, antihypertensive, calcium binding, and obesity control (1).

References___________________________________________________________________

(1) Pangestuti R, Kim SK. Bioactive Peptide of Marine Origin for the Prevention and Treatment of Non-Communicable Diseases. Mar Drugs. 2017 Mar 9;15(3):67. doi: 10.3390/md15030067.

Abstract. Non-communicable diseases (NCD) are the leading cause of death and disability worldwide. The four main leading causes of NCD are cardiovascular diseases, cancers, respiratory diseases and diabetes. Recognizing the devastating impact of NCD, novel prevention and treatment strategies are extensively sought. Marine organisms are considered as an important source of bioactive peptides that can exert biological functions to prevent and treatment of NCD. Recent pharmacological investigations reported cardio protective, anticancer, antioxidative, anti-diabetic, and anti-obesity effects of marine-derived bioactive peptides. Moreover, there is available evidence supporting the utilization of marine organisms and its bioactive peptides to alleviate NCD. Marine-derived bioactive peptides are alternative sources for synthetic ingredients that can contribute to a consumer's well-being, as a part of nutraceuticals and functional foods. This contribution focus on the bioactive peptides derived from marine organisms and elaborates its possible prevention and therapeutic roles in NCD.