Acetyl hexapeptide-8 is a topical hexapeptide that inhibits the SNAP25 component (a protein) of another family of proteins, the SNARE. Being injectable, the concern was to investigate any significant ...

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Acetyl hexapeptide-8 is a topical hexapeptide that inhibits the SNAP25 component (a protein) of another family of proteins, the SNARE. Being injectable, the concern was to investigate any significant adverse events. In a double-blind, placebo-controlled study, no adverse events were reported (1).

Pre-occupancy is that peptides in creams marketed as anti-aging can penetrate the deep layers of the skin and potentially stimulate biological activity. This other study did not detect peptide under the skin (2).

References_______________________________

(1) Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy.
Lungu C, Considine E, Zahir S, Ponsati B, Arrastia S, Hallett M.
Eur J Neurol. 2013 Mar;20(3):515-8. doi: 10.1111/ene.12009.

(2) In vitro skin penetration of acetyl hexapeptide-8 from a cosmetic formulation.
Kraeling ME, Zhou W, Wang P, Ogunsola OA.
Cutan Ocul Toxicol. 2015 Mar;34(1):46-52. doi: 10.3109/15569527.2014.894521.

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