Gamma oryzanol has recently demonstrated, in scientific studies, excellent anti-diabetic properties, interacting with Dopamine D2. Dopamine is the main neurotransmitter that controls a wide range of biological processes important in neurological, cardiovascular and metabolic homeostasis. Gamma oryzanol acts directly on pancreatic islets and improves insulin secretion in vivo, increases insulin biosynthesis, significantly decreases glucagon levels in plasma (1).
In studies on laboratory animals, Gamma oryzanol showed a potential antioxidant activity (2).
As for the musculature, it is believed that the muscular strength is improved when the exercise is accompanied by the intake of food supplements containing Gamma oryzanol (3).
The consumption of Gamma oryzanol is safe, without side effects and plays an important role, at least in part, in preventing some diseases related to an incorrect lifestyle linked to oxidative stress and high fat consumption (4).
Rice bran extracts containing Gamma oryzanol differentially inhibit colon cancer (5).
The food factor plays a crucial role in the management of cancer cases and has attracted the attention of researchers as an option to combat this disease. Both in vitro and in vivo, scientific studies have shown that rice and its derivatives show encouraging results in prevention of this disease. The mechanism of the antitumor effect is suggested, in part, through the enhancement of bioactive compounds such as vitamin E, phytic acid, Gamma oryzanol and phenols (6).
References______________________________________________
(1) A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D2 receptor signalling in mouse islet
Chisayo Kozuka, Sumito Sunagawa, Rei Ueda, Moritake Higa, Yuzuru Ohshiro, Hideaki Tanaka, Chigusa Shimizu-Okabe, Chitoshi Takayama, Masayuki Matsushita, Masato Tsutsui, Shogo Ishiuchi, Masanori Nakata, Toshihiko Yada, Jun-ichi Miyazaki, Seiichi Oyadomari, Michio Shimabukuro, Hiroaki Masuzaki
Br J Pharmacol. 2015 Sep; 172(18): 4519–4534. Published online 2015 Aug 3. doi: 10.1111/bph.13236
(2) Gamma-oryzanol rich fraction regulates the expression of antioxidant and oxidative stress related genes in stressed rat's liver
Maznah Ismail, Ghanya Al-Naqeeb, Wan Abd Aziz bin Mamat, Zalinah Ahmad
Nutr Metab (Lond) 2010; 7: 23. Published online 2010 Mar 24. doi: 10.1186/1743-7075-7-23
(3) Effects of gamma oryzanol supplementation on anthropometric measurements & muscular strength in healthy males following chronic resistance training
Saghar Eslami, Norhaizan Mohd Esa, Seyed Mohammad Marandi, Gholamali Ghasemi, Sepehr Eslami
Indian J Med Res. 2014 Jun; 139(6): 857–863.
(4) Antioxidant Activity of γ-Oryzanol: A Complex Network of Interactions
Igor Otavio Minatel, Fabiane Valentini Francisqueti, Camila Renata Corrêa, Giuseppina Pace Pereira Lima
Int J Mol Sci. 2016 Aug; 17(8): 1107. Published online 2016 Aug 9. doi: 10.3390/ijms17081107
(5) Rice Varietal Differences in Bioactive Bran Components for Inhibition of Colorectal Cancer Cell Growth
Genevieve M. Forster, Komal Raina, Ajay Kumar, Sushil Kumar, Rajesh Agarwal, Ming-Hsuan Chen, John E. Bauer, Anna M. McClung, Elizabeth P. Ryan
Food Chem. Author manuscript; available in PMC 2014 Nov 15.
Published in final edited form as: Food Chem. 2013 Nov 15; 141(2): 1545–1552. Published online 2013 Apr 17. doi: 10.1016/j.foodchem.2013.04.020
(6) Scientific Evidence of Rice By-Products for Cancer Prevention: Chemopreventive Properties of Waste Products from Rice Milling on Carcinogenesis In Vitro and In Vivo
Bee Ling Tan, Mohd Esa Norhaizan
Biomed Res Int. 2017; 2017: 9017902. Published online 2017 Jan 22. doi: 10.1155/2017/9017902
