Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid. It is incorporated into mitochondrial membranes and can be effective as a pharmacological therapy to improve mitochondrial physiol ...

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Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid. It is incorporated into mitochondrial membranes and can be effective as a pharmacological therapy to improve mitochondrial physiology in skeletal muscle aging (1).

It has a unique chemical structure with important biological consequences. By replacing the arachidonic omega-6 fatty acid in membrane phospholipids, EPA can alter the physical properties of cell membranes. Furthermore, its metabolism can give rise to anti-inflammatory and anti-thrombotic lipid mediators in contrast to pro-inflammatory and pro-thrombotic factors which tend to be produced by arachidonic acid (2).

EPA studies

Molecular Formula: C₂₀H₃₀O2

Molecular Weight: 302.45

CAS: 25378-27-2

References____________________________

(1) Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice
Matthew L Johnson, Antigoni Z Lalia, Surendra Dasari, Maximilian Pallauf, Mark Fitch, Marc K Hellerstein, Ian R Lanza
Aging Cell. 2015 Oct; 14(5): 734–743. Published online 2015 May 25. doi: 10.1111/acel.12352

(2) Prescription omega-3 fatty acid products containing highly purified eicosapentaenoic acid (EPA)
Eliot A. Brinton and R. Preston Mason
Lipids Health Dis. 2017; 16: 23.
Published online 2017 Jan 31. doi:  10.1186/s12944-017-0415-8

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