Marrubiin, a diterprene, was identified in 1984 as the first diterpene isolated from the leaves of the Horehound (Marrubium vulgare L.). It gives the bitter taste to the Horehound and to many other p ...

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Marrubiin, a diterprene, was identified in 1984 as the first diterpene isolated from the leaves of the Horehound (Marrubium vulgare L.).

It gives the bitter taste to the Horehound and to many other plants of the Laminaceae family.

Marrubiin and the organic extract suppressed coagulation, platelet aggregation and inflammatory markers. For the coagulation markers it was found that the organic extract and marrubiin significantly prolonged activated partial thromboplastin time (APTT). Fibrin and D-dimer formation were drastically decreased. These findings were observed in an ex vivo model and an obese rat model. Chemokines enhance leukocyte recruitment to inflammatory sites. TNF-α and RANTES secretion were significantly reduced by the extract and marrubiin when determined in the obese rat model relative to the controls. Calcium mobilization and TXB(2) synthesis were suppressed by the extract and marrubiin. An in vitro model was used to elucidate the antiplatelet mechanism and it was found that the extract and marrubiin inhibited platelet aggregation by inhibiting the binding of fibrinogen to glycoprotein (GP) IIb/IIIa receptor in a concentration dependent manner (1).

Marrubiin studies

Molecular Formula : C₂₀H₂₈O₄

Molecular Weight : 332.44

CAS : 465-92-9

Bibliografia_____________

(1)  The cardioprotective effects of marrubiin, a diterpenoid found in Leonotis leonurus extracts.

Mnonopi N, Levendal RA, Davies-Coleman MT, Frost CL.J Ethnopharmacol. 2011;138(1):67–75. doi: 10.1016/j.jep.2011.08.041

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