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Compendium of the most significant studies with reference to properties, intake, effects.

Arrigoni O, De Tullio MC. Ascorbic acid: much more than just an antioxidant. Biochim Biophys Acta. 2002 Jan 15;1569(1-3):1-9. doi: 10.1016/s0304-4165(01)00235-5.

Abstract. Vitamin C (ascorbic acid (AA)) is very popular for its antioxidant properties. Consequently, many other important aspects of this multifaceted molecule are often underestimated or even ignored. 

Pohanka M, Pejchal J, Snopkova S, Havlickova K, Karasova JZ, Bostik P, Pikula J. Ascorbic acid: an old player with a broad impact on body physiology including oxidative stress suppression and immunomodulation: a review. Mini Rev Med Chem. 2012 Jan;12(1):35-43. doi: 10.2174/138955712798868986.

Abstract.  The primary intention was to consider ascorbic acid not only as an antioxidant but also as a chemical compound affecting multiple pathways with a potential beneficial impact in many diseases and processes in human body.

Stabler TV, Kraus VB. Ascorbic acid accumulates in cartilage in vivo. Clin Chim Acta. 2003 Aug;334(1-2):157-62. doi: 10.1016/s0009-8981(03)00225-0. 

Abstract. To discern the role of ascorbic acid in cartilage, we conducted a dose-response study measuring ascorbic acid levels in various guinea pig tissues and fluids in response to this vitamin. To our knowledge, this is the first such study in cartilage.

Castro MA, Beltrán FA, Brauchi S, Concha II. A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid. J Neurochem. 2009 Jul;110(2):423-40. doi: 10.1111/j.1471-4159.2009.06151.x. 

Abstract. In this review, we discuss a novel function of ascorbic acid in brain energetics. It has been proposed that during glutamatergic synaptic activity neurons preferably consume lactate released from glia. The key to this energetic coupling is the metabolic activation that occurs in astrocytes by glutamate and an increase in extracellular [K(+)]. 

Gallie DR. L-ascorbic Acid: a multifunctional molecule supporting plant growth and development. Scientifica (Cairo). 2013;2013:795964. doi: 10.1155/2013/795964.

Abstract. This paper provides an overview of these approaches as well as the consequences that changes in ascorbic acid content have on plant growth and function. Discussed is the capacity of plants to tolerate changes in ascorbic acid content. The many functions that ascorbic acid serves in plants, however, will require highly targeted approaches to improve their nutritional quality without compromising their health.

Evans RM, Currie L, Campbell A. The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration. Br J Nutr. 1982 May;47(3):473-82. doi: 10.1079/bjn19820059. 

Abstract. A study was undertaken to investigate the distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration. 

Migliozzi JA. Effect of ascorbic acid on tumour growth. Br J Cancer. 1977 Apr;35(4):448-53. doi: 10.1038/bjc.1977.67. 

Abstract.The growth of tumours in guinea-pigs was observed for 20 weeks after placing them on various doses of vitamin C. Complete tumour regression occurred in 55% of those animals receiving 0-3 mg/kg/day ascorbic acid, whereas animals given 10 mg/kg/day showed tumour inhibition but no regression. 

Kamila ZP, Kołodziejczak A, Helena R. Two superior antioxidants: ferulic acid and ascorbic acid in reducing signs of photoaging - a split-face comparative study. Dermatol Ther. 2021 Dec 7:e15254. doi: 10.1111/dth.15254. 

Abstract. The assessment of the signs of photoaging in mexametric (melanin and erythema index), corneometric (hydration level), and cutometric (elasticity) examination after the treatment with ascorbic acid and ferulic acid. This study was conducted in a group of 20 women aged 39-61 (mean age 54), with Fitzpatrick skin types II and III. The study included a series of 8 treatments performed once a week.