Compendium of the most significant studies with reference to properties, intake, effects.

Barone A, Cristiano MC, Cilurzo F, Locatelli M, Iannotta D, Di Marzio L, Celia C, Paolino D. Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery. Colloids Surf B Biointerfaces. 2020 Sep;193:111152. doi: 10.1016/j.colsurfb.2020.111152.

Abstract. The aim of this work was the synthesis and physicochemical characterization of the ammonium glycyrrhizinate-loaded ultradeformable liposomes, the evaluation of drug release and permeation through stratum corneum and epidermis barrier. The in vivo anti-inflammatory effect of ammonium glycyrrhizinate-loaded ultradeformable liposomes was tested on human healthy volunteers.

Dalimov, D. N., Isaev, Y. T., & Saiitkulov, A. M. (2001). Molecular complexes of ammonium glycyrrhizate with certain medicinal agents and their interferon-inducing activity. Chemistry of natural compounds, 37(2), 151-153.

Abstract. The preparation of molecular complexes of ammonium glycyrrhizate with certain sulfamide preparations, gossypol, analgin, and salsolidine is described. Results from a study of the interferon-inducing activity of the complexes are presented.

Wojciechowski, K., Orczyk, M., Gutberlet, T., & Geue, T. (2016). Complexation of phospholipids and cholesterol by triterpenic saponins in bulk and in monolayers. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1858(2), 363-373.

Abstract. The interactions between three triterpene saponins: α-hederin, hederacoside C and ammonium glycyrrhizate with model lipids: cholesterol and dipalmitoylphosphatidylcholine (DPPC) are described. 

Yakovishin, L. A. (2021, November). Possibility of molecular complexation of ammonium glycyrrhizate with cholesterol in aqueous ethanol. In AIP Conference Proceedings (Vol. 2388, No. 1, p. 040020). AIP Publishing LLC.

Abstract. The 1 : 1 molecular complex of ammonium glycyrrhizate (GC) with cholesterol (Chol) was obtained in 80 % aqueous ethanol. GC is monoammonium salt of glycyrrhizic acid (GA). GA is the dominant triterpene glycoside from licorice roots Glycyrrhiza glabra L. Stability constant of the complex (1.6 ± 0.4) × 105 (mol/L)–1. The complex formation was studied by ATR IR-Fourier spectroscopy. Intermolecular interaction in the complex is carried out by hydrogen bond C=O…H–O and hydrophobic contacts

Mukhopadhyay, M., & Panja, P. (2008). A novel process for extraction of natural sweetener from licorice (Glycyrrhiza glabra) roots. Separation and Purification Technology, 63(3), 539-545.

Abstract. Pressurized hot water extraction (PHWE) is a very useful technique for recovering bioactive molecules from natural materials using subcritical compressed liquid water in the temperature range of 50–150 °C. A novel process has been developed for making a natural sweetener from licorice (Glycyrrhiza glabra) roots involving selective chemical reaction and easy separation, for recovering mono-ammonium glycyrrhizate (MAG) using hot water with dissolved ammonia and pressurized with carbon dioxide. 

.Wojciechowski, K., Orczyk, M., Trapp, M., & Gutberlet, T. (2016). Effect of triterpene and steroid saponins on lecithin bilayers. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 510, 150-158.

Abstract. We describe the effect of four triterpene (α-hederin, hederacoside C, ammonium glycyrrhizate, Quillaja bark saponins (QBS)) and one steroid (digitonin) saponins on lecithin and lecithin-cholesterol (4:1 mol/mol) model bilayers.