Compendium of the most significant studies with reference to properties, intake, effects.

Fiume MZ; Cosmetic Ingredients Review Expert Panel. Final report on the safety assessment of triacetin. Int J Toxicol. 2003;22 Suppl 2:1-10.

Abstract....On the basis of the available information, the CIR Expert Panel concluded that Triacetin is safe as used in cosmetic formulations.

Ogawa T, Moriwaki N, Fujii R, Tanaka K, Mori E, Saitou M, Yoshizawa H, Sakaguchi H. Triacetin as food additive in gummy candy and other foodstuffs on the market. Kitasato Arch Exp Med. 1992 Apr;65(1):33-44. 

Abstract. The qualitative and quantitative analytical methods were proposed for the simple and rapid determination of triacetin (TAc) in commercial gummy candies and other foodstuffs by gas chromatography (GC), thin layer chromatography (TLC) and infrared spectroscopy (IR).

Mekala JR, Kurappalli RK, Ramalingam P, Moparthi NR. N-acetyl l-aspartate and Triacetin modulate tumor suppressor MicroRNA and class I and II HDAC gene expression induce apoptosis in Glioblastoma cancer cells in vitro. Life Sci. 2021 Dec 1;286:120024. doi: 10.1016/j.lfs.2021.120024.

Abstract. Here, we have examined the effect of the acetates on the cell-cycle. U87MG cancer cells treated with N-acetyl l-aspartate (NAA) and sodium acetate have exhibited G1 phase cell-cycle arrest whereas U87MG cells treated with Triacetin (TA), and potassium acetate has induced G2/M cell cycle arrest.

Choi SJ, Decker EA, Henson L, Popplewell LM, McClements DJ. Stability of citral in oil-in-water emulsions prepared with medium-chain triacylglycerols and triacetin. J Agric Food Chem. 2009 Dec 9;57(23):11349-53. doi: 10.1021/jf902761h. 

Abstract. The objective of this research was to examine the impact of organic phase composition [triacetin and medium-chain triacylglycerols (MCT)] on the oil-water partitioning and chemical degradation of citral in oil-in-water emulsions. 

Lynch JW, Miles JM, Bailey JW. Effects of the short-chain triglyceride triacetin on intestinal mucosa and metabolic substrates in rats. JPEN J Parenter Enteral Nutr. 1994 May-Jun;18(3):208-13. doi: 10.1177/0148607194018003208. 

Abstract. Diets containing either triacetin (the water-soluble triglyceride of acetate) or long-chain triglycerides (LCTs) were fed to rats to determine the effects on intestinal mucosa cells and plasma substrates. Male Sprague-Dawley rats were fed one of three diets, a control diet containing 5% of energy as LCTs or one of two experimental diets that contained 30% of energy as lipid. 

Kania A, Bratek M, Majta J, Sarapata K, Gałan W, Markiewicz M, Wójcik-Augustyn A. The importance of atomic partial charges in the reproduction of intermolecular interactions for the triacetin - a model of glycerol backbone. Chem Phys Lipids. 2022 Jul;245:105203. doi: 10.1016/j.chemphyslip.2022.105203. 

Abstract. The goal of the study was to validate assigned partial charges based on the quality of the torsion profiles using optimally assigned torsional coefficients and reproduction of the condensed phase properties of triacetin.

Karlstad MD, Killeffer JA, Bailey JW, DeMichele SJ. Parenteral nutrition with short- and long-chain triglycerides: triacetin reduces atrophy of small and large bowel mucosa and improves protein metabolism in burned rats. Am J Clin Nutr. 1992 May;55(5):1005-11. doi: 10.1093/ajcn/55.5.1005.

Abstract. The effect of total parenteral nutrition with combinations of long-chain triglycerides (LCTs) and triacetin, the water-soluble triglyceride of acetate, on structural components of the gastrointestinal tract and protein metabolism was assessed in burned (30% body surface area) rats. 

Hernandez K, Garcia-Verdugo E, Porcar R, Fernandez-Lafuente R. Hydrolysis of triacetin catalyzed by immobilized lipases: effect of the immobilization protocol and experimental conditions on diacetin yield. Enzyme Microb Technol. 2011 May 6;48(6-7):510-7. doi: 10.1016/j.enzmictec.2011.02.005.

Abstract. The effect of the immobilization protocol and some experimental conditions (pH value and presence of acetonitrile) on the regioselective hydrolysis of triacetin to diacetin catalyzed by lipases has been studied. 

Dreux X, Majesté JC, Carrot C, Argoud A, Vergelati C. Viscoelastic behaviour of cellulose acetate/triacetin blends by rheology in the melt state. Carbohydr Polym. 2019 Oct 15;222:114973. doi: 10.1016/j.carbpol.2019.114973.

Abstract. The viscoelastic behaviour of cellulose acetate with a degree of substitution (DS) of 245 plasticized by triacetin was studied at short times by dynamic oscillatory measurements.

Lynch JW, Bailey JW. Dietary intake of the short-chain triglyceride triacetin vs. long-chain triglycerides decreases adipocyte diameter and fat deposition in rats. J Nutr. 1995 May;125(5):1267-73. doi: 10.1093/jn/125.5.1267.

Abstract. Diets containing either triacetin (the water-soluble triglyceride of acetate) or long-chain triglycerides (LCT) were fed to rats for 30 d to determine the effect on body weight gain and adipose tissue cellularity.