Zinc chloride is one of the many zinc compounds with antioxidant activity and with acidic property. This study was aimed to investigate separate and combined treatment effects of crocin and zinc chlo ...

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Zinc chloride is one of the many zinc compounds with antioxidant activity and with acidic property.

This study was aimed to investigate separate and combined treatment effects of crocin and zinc chloride on blood levels of zinc and metabolic and oxidative parameters in diabetic rats. Crocin (25 and 50 mg/kg) and zinc chloride (5 mg/kg) significantly recovered the decreased levels of zinc, insulin, and TAC and improved the increased levels of glucose and MDA in STZ-induced diabetic rats. In a combination treatment performed with an ineffective dose of crocin (12.5 mg/kg) and a low dose of zinc chloride (1.25 mg/kg), improving effects were observed on the above-mentioned biochemical parameters (1).

The history of zinc chloride therapy before and including Frederic E. Mohs' (1910-2002) early contributions to dermatologic oncology is presented. In 1932, Mohs devised a method of cutaneous surgery that employed zinc-chloride paste to devitalize basal or squamous cell carcinoma. This paper surveys the chemical synthesis of zinc chloride, the formulation of zinc-chloride paste as a cutaneous escharotic, and the extent to which Mohs' method compares with those of 19th and early 20th century predecessors (2).
This study examined the efficacy of calcium sulfate (CaSO4) as a carrier for intramedullary delivery of zinc chloride (ZnCl2) to treat fracture healing in a BB Wistar rat model. A non-carrier-mediated injection of 3.0 mg/kg of ZnCl2 has previously been shown to enhance fracture healing (3).

Zinc chloride is used as a hemostatic agent to control local bleeding in dental surgeries (4) and it is used in water purify as a protein coagulant (5).

Molecular Formula : Cl₂Zn

Molecular Weight : 136.3

CAS : 201-064-4

Synonyms :

• AB1002914
• AC1MHN2P
• ACMC-1BIC4
• AKOS024438088
• ANW-41104
• CHEBI:49976
• CHEMBL1200679
• Chlorure de zinc
• Chlorure de zinc anhydre
• Cl2Zn
• Cloreto de zinco
• Cloruro de cinc
• CTK2H7579
• D05ELV
• Dichlorek cynku (Chlorek cynku)
• Epitope ID:156810
• FLUX LOTOP
• Galvanizers Flux
• JIAARYAFYJHUJI-UHFFFAOYSA-L
• KS-00000UXI
• KSC377K7T
• MolPort-003-925-261
• R999
• RP20302
• RTR-024482
• SC-54095
• Sinkkikloridi
• Sinkklorio
• TR-024482
• TRA-0188177
• zinc (II) chloride
• Zinc Chloride (ca. 6.5% in Ethyl Ether, ca. 0.4mol/L)
• Zinc Chloride Solution 50%
• ZINC CHLORIDE, ACS
• Zinc chloride, ACS, 97.0% min. 250g
• ZINC CHLORIDE, U.S.P.
• Zinc Choride 0.5M solution in Tetrahydrofuran
• zinc(2+) chloride
• zinc(II)chloride
• zinc(II)-chloride
• zinc, ion (zn2+) dichloride
• zincchloride
• zinc-chloride
• zink chloride
• Zinkchlorid
• Zinkklorid
• ZnCl2

Bibliografia__________________________________________

(1) Effects of crocin and zinc chloride on blood levels of zinc and metabolic and oxidative parameters in streptozotocin-induced diabetic rats.
Asri-Rezaei S, Tamaddonfard E, Ghasemsoltani-Momtaz B, Erfanparast A, Gholamalipour S.
Avicenna J Phytomed. 2015 Sep-Oct;5(5):403-12.

(2) Frederic E. Mohs, MD, and the history of zinc chloride.
DePaolo C.
Clin Dermatol. 2018 Jul - Aug;36(4):568-575. doi: 10.1016/j.clindermatol.2017.12.001. Epub 2017 Dec 28.

(3) Local Zinc Chloride Release From a Calcium Sulfate Carrier Enhances Fracture Healing.
Krell ES, Ippolito JA, Montemurro NJ, Lim PH, Vincent RA, Hreha J, Cottrell J, Sudah SY, Muñoz MF, Pacific KP, Benevenia J, OʼConnor JP, Lin SS.
J Orthop Trauma. 2017 Mar;31(3):168-174. doi: 10.1097/BOT.0000000000000748.

(4) Review of hemostatic agents used in dentistry.
McBee WL, Koerner KR
Dent Today. 2005 Mar; 24(3):62-5; quiz 65, 61.

(5) Shen Y.H., Dempsey B.A. Synthesis and Speciation of Poly Zinc Chloride for Water Treatment. Environ Int. 1998;24:899–910.

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