The pineal gland is situated in the geometric center of the human brain and it is a unique organ that synthesizes melatonin as the signaling molecule of natural photoperiodic environment and as a potent neuronal protective antioxidant. 

The melatonin is a hormone that modulates sleep patterns and and it is normally released during the darkness within 24 hours, reaching its maximum in the middle of the night in dark conditions.

 An intact and functional pineal gland is necessary for preserving optimal human health. Unfortunately, this gland has the highest calcification rate among all organs and tissues of the human body. 

What are the causes of calcification?

• Fluoride in water.

The high level of fluoride in the human pineal gland is positively related to its calcium accumulation of the gland  (2).

• Aging.
• Human pathological disorders as the schizophrenia (3) and neurodegenerative diseases, particularly Alzheimer’s disease (4).

Males in general are known to have a higher degree of pineal calcification than females (5).

It  is very common with a reported prevalence of approximately 68–75% in adults.

How to preserve the pineal gland?

Perhaps the best way to preserve a healthy pineal gland is to rejuvenate the in situ pineal gland by decalcification and then stem cell injection into the gland (7).

References__________________________________________________________

(1) Tan DX, Xu B, Zhou X, Reiter RJ. Pineal Calcification, Melatonin Production, Aging, Associated Health Consequences and Rejuvenation of the Pineal Gland. Molecules. 2018 Jan 31;23(2):301. doi: 10.3390/molecules23020301.

(2) Luke J. Fluoride deposition in the aged human pineal gland. Caries Res. 2001 Mar-Apr;35(2):125-8. doi: 10.1159/000047443. 

(3) Sandyk R, Kay SR. Abnormal EEG and calcification of the pineal gland in schizophrenia. Int J Neurosci. 1992 Jan;62(1-2):107-11. doi: 10.3109/00207459108999764.

(4) Zhou JN, Liu RY, Kamphorst W, Hofman MA, Swaab DF. Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J Pineal Res. 2003 Sep;35(2):125-30. doi: 10.1034/j.1600-079x.2003.00065.x.

(5) Turgut AT, Karakaş HM, Ozsunar Y, Altın L, Ceken K, Alıcıoğlu B, Sönmez I, Alparslan A, Yürümez B, Celik T, Kazak E, Geyik PÖ, Koşar U. Age-related changes in the incidence of pineal gland calcification in Turkey: A prospective multicenter CT study. Pathophysiology. 2008 Jun;15(1):41-8. doi: 10.1016/j.pathophys.2008.02.001.

(6) Tan DX, Xu B, Zhou X, Reiter RJ. Pineal Calcification, Melatonin Production, Aging, Associated Health Consequences and Rejuvenation of the Pineal Gland. Molecules. 2018 Jan 31;23(2):301. doi: 10.3390/molecules23020301.