"Description" by FRanier (9976 pt) | 2020-Jan-06 16:46 |
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Polyacrylic acid is a thickener with water retention properties, an anionic synthetic polyelectrolyte.
It is used :
Dentin
This study tested whether treatment of demineralized dentin with polyacrylic acid (PAA) has any activatory or inhibitory activity on dentin matrix metalloproteinases (MMP)s or cathepsin K (CAT-K). Demineralized dentin treated with 10% polyacrylic acid activated CAT-K more than 37% phosphoric acid; 2% chlorhexidine digluconate seems to be a better inhibitor of MMPs and CAT-K than 2% benzalkonium chloride (1).
Drug delivery
Bioadhesiviness of polyacrylic acid polymers make them promising hydrogels to design topical drug delivery systems, allowing a close contact with biological substrate as well as an enhanced local concentration gradient, both factors that may improve the biological performance of the drugs. The set of results demonstrated that these hydrogels are promising to be used as topical controlled drug delivery system (2).
Molecular Formula : C3H4O2
Molecular Weight : 72,063
CAS : 9063-87-0
Synonyms :
References__________________________
(1) Effect of polyacrylic acid on dentin protease activities. Ozcan S, Seseogullari-Dirihan R, Uctasli M, Tay FR, Pashley DH, Tezvergil-Mutluay A. Dent Mater. 2015 Aug;31(8):901-6. doi: 10.1016/j.dental.2015.04.018. Epub 2015 May 21.
(2) Polyacrylic acid polymers hydrogels intended to topical drug delivery: preparation and characterization Calixto G, Yoshii AC, Rocha e Silva H, Stringhetti Ferreira Cury B, Chorilli M. Pharm Dev Technol. 2015 Jun;20(4):490-6. doi: 10.3109/10837450.2014.882941. Epub 2014 Feb 7.
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