Compendium of the most significant studies with reference to properties, intake, effects.

Bennassi CA, Semenzato A, Lucchiari M, Bettero A. Dehydroacetic acid sodium salt stability in cosmetic preservative mixtures. Int J Cosmet Sci. 1988 Feb;10(1):29-32. doi: 10.1111/j.1467-2494.1988.tb00582.x.

Abstract. Synopsis Dehydroacetic acid sodium salt Prevan (DHANa) stability in presence of other cosmetic preservatives as Bronopol, Germall 115 and Kathon CG was investigated through a HPLC method that permits simultaneous determination of binary and ternary mixtures of the above preservatives.

Baldwin AG, Bevan J, Brough D, Ledder R, Freeman S. Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid. Med Chem Res. 2018;27(3):884-889. doi: 10.1007/s00044-017-2110-8.

Abstract.  Based on the synthesis of dehydroacetic acid from N-hydroxysuccinimdyl acetoacetate, a novel series of enamine-based derivatives were synthesised in order to improve the antibacterial activity of dehydroacetic acid.

Gazzaniga A, Sangalli ME, Giordano F, Conte U, Semenzato A, Bettero A. Controlled release of dehydroacetic acid sodium salt for the stability improvement of cosmetic formulations*. Int J Cosmet Sci. 1994 Jun;16(3):105-12. doi: 10.1111/j.1467-2494.1994.tb00088.x. 

Abstract. Synopsis The kinetics of decomposition of the sodium salt of dehydroacetic acid (DHA.Na) in presence of formaldehyde and formaldehyde donors was investigated. The possibility of preparing systems capable of providing the cosmetic preparation with increasing amounts of DHA.Na corresponding to portions interacted with formaldehyde was explored.

Huang X, Zhao X, Zhu K, Ding S, Shao B. Sodium dehydroacetate induces cardiovascular toxicity associated with Ca2+ imbalance in zebrafish. Ecotoxicol Environ Saf. 2021 Jan 15;208:111613. doi: 10.1016/j.ecoenv.2020.111613.

Abstract.  Here, we utilized the advantage of zebrafish model to evaluate such effects. 

Billes F, Elečková L, Mikosch H, Andruch V. Vibrational spectroscopic study of dehydroacetic acid and its cinnamoyl pyrone derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jul 5;146:97-112. doi: 10.1016/j.saa.2015.03.010.

Abstract. The infrared and Raman spectra of dehydroacetic acid and some of its derivatives were measured.

Zema L, Sangalli ME, Maroni A, Foppoli A, Bettero A, Gazzaniga A. Active packaging for topical cosmetic/drug products: a hot-melt extruded preservative delivery device. Eur J Pharm Biopharm. 2010 Jun;75(2):291-6. doi: 10.1016/j.ejpb.2010.03.007.

Abstract. A delivery device intended for the prolonged release of antimicrobial agents, able to enhance the stability profile of liquid/semi-solid cosmetic/pharmaceutical products for topical application, was proposed in the present study.