Compendium of the most significant studies with reference to properties, intake, effects.

Moloughney JG, Weisleder N. Poloxamer 188 (p188) as a membrane resealing reagent in biomedical applications. Recent Pat Biotechnol. 2012 Dec;6(3):200-11. doi: 10.2174/1872208311206030200.

O'Keefe JH, Grines CL, DeWood MA, Schaer GL, Browne K, Magorien RD, Kalbfleisch JM, Fletcher WO Jr, Bateman TM, Gibbons RJ. Poloxamer-188 as an adjunct to primary percutaneous transluminal coronary angioplasty for acute myocardial infarction. Am J Cardiol. 1996 Oct 1;78(7):747-50. doi: 10.1016/s0002-9149(96)00414-6.

Casella JF, Barton BA, Kanter J, Black LV, Majumdar S, Inati A, Wali Y, Drachtman RA, Abboud MR, Kilinc Y, Fuh BR, Al-Khabori MK, Takemoto CM, Salman E, Sarnaik SA, Shah N, Morris CR, Keates-Baleeiro J, Raj A, Alvarez OA, Hsu LL, Thompson AA, Sisler IY, Pace BS, Noronha SA, Lasky JL 3rd, de Julian EC, Godder K, Thornburg CD, Kamberos NL, Nuss R, Marsh AM, Owen WC, Schaefer A, Tebbi CK, Chantrain CF, Cohen DE, Karakas Z, Piccone CM, George A, Fixler JM, Singleton TC, Moulton T, Quinn CT, de Castro Lobo CL, Almomen AM, Goyal-Khemka M, Maes P, Emanuele M, Gorney RT, Padgett CS, Parsley E, Kronsberg SS, Kato GJ, Gladwin MT. Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial. JAMA. 2021 Apr 20;325(15):1513-1523. doi: 10.1001/jama.2021.3414.

Prancan AV, Ecanow B, Bernardoni RJ, Sadove MS. Poloxamer 188 as vehicle for injectable diazepam. J Pharm Sci. 1980 Aug;69(8):970-1. doi: 10.1002/jps.2600690828.

Merchant FA, Holmes WH, Capelli-Schellpfeffer M, Lee RC, Toner M. Poloxamer 188 enhances functional recovery of lethally heat-shocked fibroblasts. J Surg Res. 1998 Feb 1;74(2):131-40. doi: 10.1006/jsre.1997.5252.

Hou X, Liang J, Yang X, Bai J, Yang M, Qiao N, Hu Z, Yan X, Shi Y. Poloxamer188-based nanoparticles improve the anti-oxidation and anti-degradation of curcumin. Food Chem. 2021 Nov 25:131674. doi: 10.1016/j.foodchem.2021.131674.

Sharma V, Stebe K, Murphy JC, Tung L. Poloxamer 188 decreases susceptibility of artificial lipid membranes to electroporation. Biophys J. 1996 Dec;71(6):3229-41. doi: 10.1016/S0006-3495(96)79516-4.

Grapentin C, Müller C, Kishore RSK, Adler M, ElBialy I, Friess W, Huwyler J, Khan TA. Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal Antibody Formulations Containing Poloxamer 188. J Pharm Sci. 2020 Aug;109(8):2393-2404. doi: 10.1016/j.xphs.2020.03.010.

Gibbs WJ, Hagemann TM. Purified poloxamer 188 for sickle cell vaso-occlusive crisis. Ann Pharmacother. 2004 Feb;38(2):320-4. doi: 10.1345/aph.1D223.

Catalan-Figueroa J, García MA, Contreras P, Boisset CB, Gonzalez PM, Fiedler JL, Pérez MF, Morales JO. Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia. Mol Pharm. 2021 Feb 1;18(2):743-750. doi: 10.1021/acs.molpharmaceut.0c00623.

Merchant FA, Holmes WH, Capelli-Schellpfeffer M, Lee RC, Toner M. Poloxamer 188 enhances functional recovery of lethally heat-shocked fibroblasts. J Surg Res. 1998 Feb 1;74(2):131-40. doi: 10.1006/jsre.1997.5252.

Göke K, Roese E, Bunjes H. Heat Treatment of Poloxamer-Stabilized Triglyceride Nanodispersions: Effects and Underlying Mechanism. Mol Pharm. 2018 Aug 6;15(8):3111-3120. doi: 10.1021/acs.molpharmaceut.8b00202.

 Carr ME Jr, Powers PL, Jones MR. Effects of poloxamer 188 on the assembly, structure and dissolution of fibrin clots. Thromb Haemost. 1991 Nov 1;66(5):565-8.

Aoki N, Tamura M, Ohyashiki JH, Sugaya M, Hisatomi H. Poloxamer 188 enhances apoptosis in a human leukemia cell line. Mol Med Rep. 2010 Jul-Aug;3(4):669-72. doi: 10.3892/mmr_00000314.

 Mina EW, Lasagna-Reeves C, Glabe CG, Kayed R. Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro. J Mol Biol. 2009 Aug 21;391(3):577-85. doi: 10.1016/j.jmb.2009.06.024.

 Bareford L, Peng H, Ali A, Kolwyck D, Dickens J. Development of a rapid and reliable analytical method for screening poloxamer 188 for use in cell culture process. Biotechnol Prog. 2019 May;35(3):e2792. doi: 10.1002/btpr.2792.