Compendium of the most significant studies with reference to properties, intake, effects.

Magnesium stearate as lubricant

Goh WP, Montoya Sanavia A, Ghadiri M. Effect of Mixer Type on Particle Coating by Magnesium Stearate for Friction and Adhesion Modification. Pharmaceutics. 2021 Aug 5;13(8):1211. doi: 10.3390/pharmaceutics13081211.

Abstract.  The optimal percentage of magnesium stearate is found to be approximately 1% by weight for all mixer types, as the addition of higher amounts of lubricant does not further improve the flowability of the material.

Patel DB, Dave RH. Predicting lubricants effect on tablet sticking using ketoprofen as model drug and evaluating sticking propensity using different metals and powder rheology. Int J Pharm. 2021 Sep 5;606:120913. doi: 10.1016/j.ijpharm.2021.120913.

Abstract. A model formulation comprising ketoprofen and microcrystalline cellulose was used to predict the effect of magnesium stearate and sodium stearyl fumarate on the occurrence of tablet sticking relative to different punch metals.

Calahan JL, Paul S, Yanez EG, DeNeve D, Sun CC, Munson EJ. The impact of solid-state form, water content and surface area of magnesium stearate on lubrication efficiency, tabletability, and dissolution. Pharm Dev Technol. 2021 Feb;26(2):150-156. doi: 10.1080/10837450.2020.1839763.

Abstract. It is concluded that the choice of the most appropriate grade of Magnesium stearate for a particular formulation depends on a comprehensive evaluation of the impact of Magnesium stearate  properties on lubrication efficiency, tabletability and dissolution.

Magnesium stearate in tablets

Tranová T, Macho O, Loskot J, Mužíková J. Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for orally disintegrating tablets. Eur J Pharm Sci. 2021 Oct 8;168:106035. doi: 10.1016/j.ejps.2021.106035.

Abstract.  Magnesium stearate reduced the ejection force more effectively than sodium stearyl fumarate. Prosolv® ODT G2 tablets exhibited the highest tensile strength and shortest disintegration time.

Furukawa R, Singh R, Ierapetritou M. Experimental investigation and modelling of tensile strength of pharmaceutical tablets based on shear force applied by feed frame paddles. Int J Pharm. 2021 Sep 5;606:120908. doi: 10.1016/j.ijpharm.2021.120908.

Abstract.   It is found that within the investigated range of tablet press parameters and the amount of magnesium stearate, the feed frame speed and the amount of magnesium stearate have an impact on the tensile strength.