Hyperuricemia is a risk factor for chronic kidney disease.

In particular, high doses of fructose can cause hyperuricemia. In the kidney, urato crystals can be deposited that can result in tubular tubal kidney fibrosis with consequences of kidney dysfunction.

Components that help in antihyperuricemic action are substances that can contribute to reducing uric acid levels in the blood. Here are some examples

• Allopurinol. A medication that reduces the production of uric acid in the body.
• Febuxostat. Another medication that inhibits the enzyme xanthine oxidase, reducing uric acid production.
• Water. Adequate hydration can help dilute uric acid and promote its elimination through urine.
• Vitamin C. May help reduce uric acid levels in the blood.
• Cherries. Have been associated with reducing uric acid levels and preventing gout attacks.
• Dietary Fiber. Helps reduce uric acid levels through absorption and elimination.
• Low-Fat Dairy Products. Can help reduce uric acid levels.
• Coffee. Some studies suggest that coffee may reduce uric acid levels, although results are mixed.
• Omega-3 Fatty Acids. Can help reduce inflammation associated with high uric acid levels.
• Limiting Intake of High-Purine Foods. Foods like red meats, organ meats, and certain types of fish are high in purines and can increase uric acid levels.

The reports  provided on Tiiips website are for informational purposes only and should not replace medical advice. Always consult a healthcare professional before making health-related decisions.

Components that can contribute to or exacerbate hyperuricemia include various factors that can increase uric acid levels in the blood. Here are some examples

• High-Purine Foods. Foods like red meats, organ meats, and certain types of fish can increase uric acid levels.
• Alcohol. Excessive consumption of alcohol, especially beer and strong spirits, can increase uric acid levels.
• High-Fructose Diet. Fructose, particularly in sugary drinks and syrups, can increase uric acid levels.
• Overweight and Obesity. A high body mass index can increase the risk of hyperuricemia.
• Dehydration. Lack of adequate hydration can concentrate uric acid in the blood.
• Kidney Failure. Reduced kidney function can lead to an accumulation of uric acid.
• Stress. Physical and emotional stress can affect uric acid levels.
• Vitamin C Deficiency. Low intake of vitamin C can be associated with higher uric acid levels.
• Genetic Factors. Genetic predisposition can affect uric acid levels and the risk of hyperuricemia.

Studies

Liu XZ, Xu X, Zhu JQ, Zhao DB.  Association between three non-insulin-based indexes of insulin resistance and hyperuricemia.   Clin Rheumatol. 2019 Jul 12. doi: 10.1007/s10067-019-04671-6.

Wang Q, Wen X, Kong J.  Recent Progress on Uric Acid Detection: A Review.   Crit Rev Anal Chem. 2019 Jul 12:1-17. doi: 10.1080/10408347.2019.1637711.

Wu MJ, Tsai SF, Lee CT, Wu CY.  The Predictive Value of Hyperuricemia on Renal Outcome after Contrast-Enhanced Computerized Tomography.   J Clin Med. 2019 Jul 10;8(7). pii: E1003. doi: 10.3390/jcm8071003.

Albert D, Scudder PN, Bagley P, Saag KG.   Vascular Consequences of Hyperuricemia and Hypouricemia.  Rheum Dis Clin North Am. 2019 Aug;45(3):453-464. doi: 10.1016/j.rdc.2019.04.005

Zhang L, Wan Q, Zhou Y, Xu J, Yan C, Ma Y, Xu M, He R, Li Y, Zhong X, Cheng G, Lu Y.   Age-related and gender-stratified differences in the association between high triglyceride and risk of hyperuricemia.  Lipids Health Dis. 2019 Jul 4;18(1):147. doi: 10.1186/s12944-019-1077-5.

Martins de Sá Müller C, Coelho GB, Carolina de Paula Michel Araújo M, Saúde-Guimarães DA.   Lychnophora pinaster ethanolic extract and its chemical constituents ameliorate hyperuricemia and related inflammation.  J Ethnopharmacol. 2019 Jun 25;242:112040. doi: 10.1016/j.jep.2019.112040.

Tourzel E, Munck S, Fournier JP, Maisonneuve H.    Factors influencing urate Lowering Therapies prescription for asymptomatic hyperuricemia by general practitioners: a qualitative study.  Int J Clin Pract. 2019 Jun 28:e13383. doi: 10.1111/ijcp.13383.

Kim IY, Han KD, Kim DH, Eun Y, Cha HS, Koh EM, Lee J, Kim H.  Women with Metabolic Syndrome and General Obesity Are at a Higher Risk for Significant Hyperuricemia Compared to Men.   J Clin Med. 2019 Jun 12;8(6). pii: E837. doi: 10.3390/jcm8060837.

Jeon HJ, Oh J, Shin DH.   Urate-lowering agents for asymptomatic hyperuricemia in stage 3 - 4 chronic kidney disease: Controversial role of kidney function. PLoS One. 2019 Jun 17;14(6):e0218510. doi: 10.1371/journal.pone.0218510.

Kubota M.   Hyperuricemia in Children and Adolescents: Present Knowledge and Future Directions.   Nutr Metab. 2019 May 2;2019:3480718. doi: 10.1155/2019/3480718.