Multiple factors cause and develop the clinical signs of aging. In the epidermis. the loss of dermal proteins, the decrease in collagen and elastin levels is clinically manifested as wrinkles. the skin is functionally affected anatomically and by aging.

Photoaging and photo-oxidative damage were induced in human skin explants by artificial solar radiation.

Photoaging and photo-oxidative damage Solar radiation is responsible for photoaging and photo-oxidative damage on human skin.

The bioprogressive philosophy, with assistance of modern technological developments, such as microgravity-producing devices and techniques, enables personalized and targeted therapeutic approach that seems the most effective in rehabilitation and prevention of neuro-myo-sensory disorders that compromise the homeostatic body harmony, particularly in old age. The review defines the aging, discusses the most common physical dysfunctions, linked to posture, balance, or gait, and gives cues to modern antiaging rehabilitative approaches (1).

It can be reasonably argued that drugs used to treat age-related diseases, such as diabetes, cancer, hypertension, ischemic heart disease, and others, can be viewed from the perspective of anti-aging drugs.

Conventional cosmetic procedures and cosmeceuticals work together with nutritious diet, exercise, dental hygiene, hormonal balance, stress reduction, smoking and pollution avoidance, and healthy sleep patterns for a better effect on antiaging (2).

Is rapamycin the solution to the problem of aging? This study discusses and clarifies why it is more dangerous not to use anti-aging drugs than to use them and how rapamycin-based drug combinations have already been implemented for potential life extension in humans (3). However, studies on the side effects of this substance are still needed.

Recent research shows that protein S, a vitamin K-dependent protein, may prevent the cytokine storm observed in COVID-19 cases. Reduced activation of protein S due to pneumonia-induced vitamin K depletion has been correlated with increased thrombogenicity and fatal outcomes in covid-19 patients. This study presents the latest scientific evidence on vitamin K and its role in preventing age-associated diseases and/or improving the efficacy of medical treatments in ˃50-year-old mature adults (4).

Components that help in anti-aging are substances that can contribute to slowing down the signs of aging. Here are some examples

• Antioxidants. Substances like vitamin C, vitamin E, and beta-carotene can protect the skin from free radical damage.
• Retinoids. Derived from vitamin A, retinoids can reduce wrinkles and improve skin texture.
• Peptides. Stimulate collagen and elastin production, helping to make the skin firmer and smoother.
• Hyaluronic Acid. Helps maintain skin hydration, reducing the appearance of fine lines and wrinkles.
• Sun Protection. Daily use of sunscreen can prevent damage caused by UV rays, a major cause of skin aging.
• Alpha Hydroxy Acids (AHA). Help exfoliate the skin, removing dead cells and promoting cell renewal.
• Coenzyme Q10. Protects the skin from oxidative stress and improves its elasticity.
• Green Tea. Rich in antioxidants, green tea can protect the skin from environmental damage.
• Omega-3 Fatty Acids. Found in fatty fish and flaxseeds, they can reduce inflammation and nourish the skin.
• Resveratrol. Found in grapes and red wine, it has antioxidant properties and can protect the skin from aging.

The reports  provided on Tiiips website are for informational purposes only and should not replace medical advice. Always consult a healthcare professional before making health-related decisions.

Components that can contribute to or exacerbate aging include various factors that can accelerate the signs of aging. Here are some examples

• UV Rays. Prolonged exposure to the sun without protection can cause skin damage and accelerate aging.
• Cigarette Smoke. Smoking can damage the skin, reducing blood flow and speeding up the aging process.
• Alcohol. Alcohol can dehydrate the skin and negatively affect its elasticity.
• Poor Nutrient Diet. A diet lacking in vitamins, minerals, and antioxidants can contribute to premature skin aging.
• Environmental Pollution. Exposure to pollutants can damage the skin and accelerate aging.
• Chronic Stress. Stress can negatively impact skin health and accelerate aging.
• Lack of Sleep. Insufficient sleep can affect skin regeneration and contribute to aging.
• Repetitive Facial Expressions. Frequent facial movements can lead to the formation of lines and wrinkles.
• Dehydration. Lack of adequate hydration can make the skin drier and accentuate fine lines.
• Excessive Sugar Consumption. A diet high in sugars can cause glycation, damaging collagen and elastin fibers in the skin.

References________________________________________________________________________________________

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(2) Saluja SS, Fabi SG. A Holistic Approach to Antiaging as an Adjunct to Antiaging Procedures: A Review of the Literature. Dermatol Surg. 2017 Apr;43(4):475-484. doi: 10.1097/DSS.0000000000001027.

(3) Blagosklonny MV. Rapamycin for longevity: opinion article. Aging (Albany NY). 2019 Oct 4;11(19):8048-8067. doi: 10.18632/aging.102355. 

(4) Popa DS, Bigman G, Rusu ME. The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases. Antioxidants (Basel). 2021 Apr 6;10(4):566. doi: 10.3390/antiox10040566. 

Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol. 2012 Jul 1;4(3):308-19. doi: 10.4161/derm.22804.

 Rivers JK. The role of cosmeceuticals in antiaging therapy. Skin Therapy Lett. 2008 Nov-Dec;13(8):5-9.

Garre A, Narda M, Valderas-Martinez P, Piquero J, Granger C. Antiaging effects of a novel facial serum containing L-Ascorbic acid, proteoglycans, and proteoglycan-stimulating tripeptide: ex vivo skin explant studies and in vivo clinical studies in women. Clin Cosmet Investig Dermatol. 2018 May 29;11:253-263. doi: 10.2147/CCID.S161352.

Carapeto PV, Aguayo-Mazzucato C. Effects of exercise on cellular and tissue aging. Aging (Albany NY). 2021 May 13;13. doi: 10.18632/aging.203051.

Wang X, Zhang Z, Zhang S, Yang F, Yang M, Zhou J, Hu Z, Xu X, Mao G, Chen G, Xiang W, Sun X, Xu N. Antiaging compounds from marine organisms. Food Res Int. 2021 May;143:110313. doi: 10.1016/j.foodres.2021.110313.

Zerbinati N, Sommatis S, Maccario C, Di Francesco S, Capillo MC, Rauso R, Herrera M, Bencini PL, Guida S, Mocchi R. The Anti-Ageing and Whitening Potential of a Cosmetic Serum Containing 3-O-ethyl-l-ascorbic Acid. Life (Basel). 2021 Apr 29;11(5):406. doi: 10.3390/life11050406.

Benameur T, Panaro MA, Porro C. The antiaging role of oxytocin. Neural Regen Res. 2021 Dec;16(12):2413-2414. doi: 10.4103/1673-5374.313030.

 Wu Y, Cao K, Zhang W, Zhang G, Zhou M. Protective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts. Skin Pharmacol Physiol. 2021 Apr 13:1-9. doi: 10.1159/000514496.

 Abedini E, Khodadadi E, Zeinalzadeh E, Moaddab SR, Asgharzadeh M, Mehramouz B, Dao S, Samadi Kafil H. A Comprehensive Study on the Antimicrobial Properties of Resveratrol as an Alternative Therapy. Evid Based Complement Alternat Med. 2021 Mar 16;2021:8866311. doi: 10.1155/2021/8866311