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 | "Descrizione" by A_Partyns (12876 pt) | 2019-Nov-06 18:40 |
| Evaluation | N. Experts | Evaluation | N. Experts |
|---|---|---|---|
| 1 | 6 | ||
| 2 | 7 | ||
| 3 | 8 | ||
| 4 | 9 | ||
| 5 | 10 |
Shark liver oil is extracted from different species of sharks: Echinorhinus brucus, Centrophorus squamosus, Isistius brasiliensis, Etmopterus spinax, Etmopterus molleri, etc.
This oil contains glycerolipids Alkyl-ether-lipids (AEL) which have a long fatty alkyl chain connected to the glycerol unit. AEL exerts stimulating activity on the immune system (1) and anti-tumor activity (2), wound healing activities (3), dermatitis (4)
Echinorhinus brucus liver oil contains squalene (35%), docosahexaenoic acid (18%), eicosapentaenoic acid (18%), palmitic acid (15%), oleic acid (12%), stearic acid (8%), as well as vitamin A (17.08 mg/100 g), vitamin D (15.04 mg/100 g), vitamin K (11.45 mg/100 g) (5).
The most abundant component, squalene, triterpene, is structurally similar to beta-carotene, coenzyme Q10 and vitamins A, K and E and performs cardio-protective action (6).
References______________________________
(1) Effects of dietary alkylglycerols in lactating rats on immune responses in pups. Oh SY, Jadhav LS. Pediatr Res. 1994 Sep;36(3):300-5.
(2) Natural alkylglycerols restrain growth and metastasis of grafted tumors in mice. Pedrono F, Martin B, Leduc C, Le Lan J, Saïag B, Legrand P, Moulinoux JP, Legrand AB. Nutr Cancer. 2004;48(1):64-9.
(3) An update on the therapeutic role of alkylglycerols. Iannitti T, Palmieri B. Mar Drugs. 2010 Aug 5;8(8):2267-300. doi: 10.3390/md8082267.
(4) Shark liver oil as a supporting therapy in atopic dermatitis. Nowicki R, Barańska-Rybak W. Pol Merkur Lekarski. 2007 Apr;22(130):312-3.
(5) Biochemical Characterization of Liver Oil of Echinorhinus brucus (Bramble Shark) and Its Cytotoxic Evaluation on Neuroblastoma Cell Lines (SHSY-5Y). Venugopal V, Kumaran AK, Sekhar Chatterjee N, Kumar S, Kavilakath S, Nair JR, Mathew S. Scientifica (Cairo). 2016;2016:6294030. doi: 10.1155/2016/6294030.
(6) Squalene: A natural triterpene for use in disease management and therapy. Reddy LH, Couvreur P. Adv Drug Deliv Rev. 2009 Dec 17;61(15):1412-26. doi: 10.1016/j.addr.2009.09.005.
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