Phentermine (2-methyl-1-phenylpropan-2-amine) is a sympathomimetic amine, a strong inhibitor of the vector of noradrenaline and works as an appetite suppressant by stimulating the neurons of the arched nucleus of the hypothalamic proopiomelanocortin.
It was approved by the U.S. Food and Drug Administration in 1959 and approved in 2012 in a combination of immediate-release phentermine and long-release topiramate, for the treatment of obese or overweight patients with comorbid conditions.
Topiramate (2, 3, 4, 5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate) is an antiepileptic, gamma-aminobutyric acid antagonist with the ability to inhibit compulsive desire for food and engaging behavior.
The phentermine/tocopyramate combination is a combination therapy (1) to be combined with a low-calorie diet and increased exercise to achieve effective weight loss in obesity (2).
Phentermine studies
Molecular Formula: C10H15N
Molecular Weight: 149.23 g/mol
CAS: 122-09-8 12674-13-4 9008-94-0
EC Number: 204-522-1
NSC Number: 759163
UN Number: 1851
UNII: C045TQL4WP
MDL number MFCD00059195
PubChem Substance ID 329820023
Sinonimi:
- Duromine
- Phenterminum
- Fentermina
- Normephentermine
- Mirapront
- Obermine
- Lonamin
- Phentrol
- Lipopill
- Fastin
- 1,1-Dimethyl-2-phenylethylamine
- 2-methyl-1-phenylpropan-2-amine
- Adipex-P
- 2-Phenyl-tert-butylamine
- 2-Amino-2-methyl-1-phenylpropane
- Phenyl-tert-butylamine
- alpha,alpha-Dimethylbenzeneethanamine
- alpha-Benzylisopropylamine
- Benzeneethanamine, alpha,alpha-dimethyl-
- Phenyl-tertiary-butylamine
- Ethanamine, 1,1-dimethyl-2-phenyl-
References______________________________________________
(1) New obesity agents: lorcaserin and phentermine/topiramate. Fleming JW, McClendon KS, Riche DM. Ann Pharmacother. 2013 Jul-Aug;47(7-8):1007-16. doi: 10.1345/aph.1R779.
(2) A Randomized, Double-Blind, Placebo-Controlled, Pharmacokinetic and Pharmacodynamic Study of a Fixed-Dose Combination of Phentermine/Topiramate in Adolescents with Obesity. Hsia DS, Gosselin NH, Williams J, Farhat N, Marier JF, Shih W, Peterson C, Siegel R. Diabetes Obes Metab. 2019 Nov 6. doi: 10.1111/dom.13910.
