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 | "Descrizione" by AColumn (9309 pt) | 2019-Nov-17 10:45 |
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In the scientific literature, two forms of pantoprazole are treated: mono and sesquidrate.
Pantoprazole sodium sesquihydrate is used as a proton pump inhibitor, as a potent inhibitor of gastric acid secretion and is widely used for the treatment of gastroesophageal reflux, dyspepsia and peptic ulcer.
It also exerts an anti-inflammatory action (1) in gastric and endothelial parietal cells.
The increase in the number of drugs containing pantoprazole sodium sesquihydrate raises questions about its effectiveness and generic substitutability. This study examined 6 generic drugs and performed a series of tests to monitor their efficacy as pantoprazole becomes unstable at low pH values (2).
Like all drugs it can cause side effects. Always consult your doctor.
Pantoprazole sodium sesquihydrate studies
Molecular Formula: C32H34F4N6Na2O11S2
Molecular Weight: 864.8 g/mol
CAS: 164579-32-2
EC Number: 605-368-1
Synonyms:
References_________________________________________________
(1) Pantoprazole, an FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated protein kinase. Zeng X, Liu L, Zheng M, Sun H, Xiao J, Lu T, Huang G, Chen P, Zhang J, Zhu F, Li H, Duan Q Oncotarget. 2016 Apr 19; 7(16):22460-73.
(2) Assessment of the pharmaceutical quality of marketed enteric coated pantoprazole sodium sesquihydrate products. Mostafa HF, Ibrahim MA, Mahrous GM, Sakr A. Saudi Pharm J. 2011 Apr;19(2):123-7. doi: 10.1016/j.jsps.2011.01.001.
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