Lansoprazolo è un composto chimico, un derivato benzimidazolico solfossido è un membro delle piridine e dei benzimidazoli.

Si presenta in forma di polvere bianca, fine.

A cosa serve e dove si usa

Assumere solo sotto controllo medico

E' uno degli inibitori della pompa protonica (omeprazolo, pantoprazolo, esomeprazolo, rabeprazolo e ilaprazolo) come potente inibitore della secrezione di acido gastrico e viene ampiamente utilizzato per la terapia del reflusso gastroesofageo, della dispepsia e dell'ulcera peptica (1).

E' uno dei farmaci meglio tollerati e poiché ha una certa sensibilità agli acidi, viene normalmente somministrato sotto forma di capsule contenenti granuli rivestiti di sostanze enteriche per prevenire la decomposizione gastrica e per aumentare la biodisponibilità.

Per le sue proprietà antinfiammatorie inibisce l'induzione di diversi mediatori infiammatori con conseguente prevenzione di lesioni epatiche acute del fegato (2).

L'integrazione di Lansoprazolo (50 mg/kgBW) per 4 settimane ha prodotto significative diminuzioni della cisti renale e un miglioramento della funzione renale attraverso la riduzione della creatinina plasmatica e dell'azoto dell'urea nel sangue (3).

Come tutti i farmaci può causare effetti collaterali. Consultare sempre il medico. 

Lansoprazolo studi

Caratteristiche tipiche del prodotto commerciale Lansoprazolo 

Appearance	White powder
Boiling Point	555.8±60.0 °C at 760 mmHg
Melting Point	178-182°C dec.
Flash Point	289.9±32.9°C
Density	1.5±0.1 g/cm3
Loss on drying	≤2.0%
Heavy metals	≤10 ppm
Water	≤1.0%
Sulphated ash	≤0.5%/g
Residue on ignition	≤0.1%
Safety

• Formula molecolare  C₁₆H₁₄F₃N₃O₂S
• Peso molecolare  369.4 g/mol
• Massa esatta   369.075867
• CAS: 103577-45-3   138530-94-6
• UNII    0K5C5T2QPG
• EC Number   2017-001-1
• DSSTox Substance ID  DTXSID4023200
• IUPAC  2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
• InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)  
• InChl Key      MJIHNNLFOKEZEW-UHFFFAOYSA-N
• SMILES   CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F
• NSC    758710    758638
• MDL number MFCD00866873
• PubChem Substance ID 329750232

Sinonimi:

• Prevacid
• Lanzopral
• Blason
• Takepron
• Ketian
• Zoton
• Lancid
• Lansoprazolum
• Lanston
• Lanproton
• Prezal
• Lansopep
• Ulpax
• Lasoprol
• Lanz
• Mesactol
• Bamalite
• Pro Ulco
• Monolitum
• Lanzol
• Lansoprazol
• Lanzul
• Agopton
• PrevOnco
• Limpidex
• Lanzo
• Ogastro
• Biuret Gr
• Lanzor
• 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole
• 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole
• 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
• 1H-Benzimidazole, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-
• 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methylsulfinyl]-1H-benzimidazole
• 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)-1H-benzimidazole
• 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
• 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
• 1H-Benzimidazole, 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-
• 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
• 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole
• 2-{[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl}-1H-benzimidazole
• 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylsulfinyl]-1H-benzimidazole
• 2-[({3-methyl-4-[(2,2,2-trifluoroethyl)oxy]pyridin-2-yl}methyl)sulfinyl]-1H-benzimidazole
• 2-[[3-methyl-4-[2,2,2-tris(fluoranyl)ethoxy]pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
• 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl] methyl] sulfinyl] benzimidazole
• 2-{[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methanesulfinyl}-1H-1,3-benzodiazole
• 2-({[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole
• 2-({3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl} sulphinylbenzimidazole;2-({3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl} sulphinylbenzimidazole

Bibliografia________________________________________

(1) Pharmacological and clinical profile of lansoprazole (Takepron IV injection 30 mg)]. Inatomi N, Nitta K, Sakurai Y. Nihon Yakurigaku Zasshi. 2008 Feb;131(2):149-56.

(2) The Proton Pump Inhibitor Lansoprazole Has Hepatoprotective Effects in In Vitro and In Vivo Rat Models of Acute Liver Injury. Nakatake R, Hishikawa H, Kotsuka M, Ishizaki M, Matsui K, Nishizawa M, Yoshizawa K, Kaibori M, Okumura T. Dig Dis Sci. 2019 Oct;64(10):2854-2866. doi: 10.1007/s10620-019-05622-6.

(3)  Lansoprazole reduces renal cyst in polycystic kidney disease via inhibition of cell proliferation and fluid secretion.  Nantavishit J, Chatsudthipong V, Soodvilai S.  Biochem Pharmacol. 2018 Aug;154:175-182. doi: 10.1016/j.bcp.2018.05.005.