Compendio degli studi più significativi con riferimento a proprietà, assunzione, effetti.

Calleja LF, Belmont-Díaz JA, Medina-Contreras O, Quezada H, Yoval-Sánchez B, Campos-García J, Rodríguez-Zavala JS. Omeprazole as a potent activator of human cytosolic aldehyde dehydrogenase ALDH1A1. Biochim Biophys Acta Gen Subj. 2020 Jan;1864(1):129451. doi: 10.1016/j.bbagen.2019.129451.

Abstract. Although omeprazole is used to reduce stomach gastric acid production, in the present work this drug is described as the most potent activator of human ALDH1A1 reported yet.

Abbas MK, Zaidi ARZ, Robert CA, Thiha S, Malik BH. The Safety of Long-term Daily Usage of a Proton Pump Inhibitor: A Literature Review. Cureus. 2019 Sep 4;11(9):e5563. doi: 10.7759/cureus.5563.

Abstract. Proton pump inhibitors (PPIs) are amongst the most prescribed medications in the whole world due to their effectiveness and safety profile. However, doubts have arisen about its safety in long term use and have been associated with an increased risk of developing gastric cancer. We aim to study if there is an association between chronic PPI use and the risk of gastric cancer. If this is true, we would like to know the duration of use at which the risk of cancer is high. 

Sharma P. Reliving 25 years of Experience with Omeprazole in Acid-peptic Diseases. J Assoc Physicians India. 2018 Aug;66(8):72-78.

Abstract. This review is an objective overview of the efficacy and safety of PPIs in APDs, with special focus on omeprazole.

Ronchi F, Sereno A, Paide M, Sacré P, Guillaume G, Stéphenne V, Goole J, Amighi K. Development and evaluation of an omeprazole-based delayed-release liquid oral dosage form. Int J Pharm. 2019 Aug 15;567:118416. doi: 10.1016/j.ijpharm.2019.06.007.

Abstract. In this study, a new technology has been developed that consists of multi-layered particles suspended extemporaneously in a syrup, using omeprazole as a model drug. 

Bazzaz BSF, Fakori M, Khameneh B, Hosseinzadeh H.  Effects of Omeprazole and Caffeine Alone and in Combination with Gentamicin and Ciprofloxacin Against Antibiotic Resistant Staphylococcus Aureus and Escherichia Coli Strains. J Pharmacopuncture. 2019 Mar;22(1):49-54. doi: 10.3831/KPI.2019.22.006.

Dutta P, Funston W, Mossop H, Ryan V, Jones R, Forbes R, Sen S, Pearson J, Griffin SM, Smith JA, Ward C, Forrest IA, Simpson AJ. Randomised, double-blind, placebo-controlled pilot trial of omeprazole in idiopathic pulmonary fibrosis. Thorax. 2019 Apr;74(4):346-353. doi: 10.1136/thoraxjnl-2018-212102..

Abstract. Cough is a common, disabling symptom of idiopathic pulmonary fibrosis (IPF), which may be exacerbated by acid reflux. Inhibiting gastric acid secretion could potentially reduce cough. This study aimed to determine the feasibility of a larger, multicentre trial of omeprazole for cough in IPF, to assess safety and to quantify cough.

Lindsay J, Mudge S, Thompson GR 3rd. Effects of Food and Omeprazole on a Novel Formulation of Super Bioavailability Itraconazole in Healthy Subjects. Antimicrob Agents Chemother. 2018 Nov 26;62(12):e01723-18. doi: 10.1128/AAC.01723-18. 

Abstract. This study evaluated the pharmacokinetic profile of SUBA itraconazole under fasting and fed conditions, as well as with the concomitant administration of a proton pump inhibitor.

Qi Q, Wang R, Liu L, Zhao F, Wang S. Comparative effectiveness and tolerability of esomeprazole and omeprazole in gastro-esophageal reflux disease: A systematic review and meta-analysis. Int J Clin Pharmacol Ther. 2015 Oct;53(10):803-10. doi: 10.5414/CP202396.

Abstract. This study aims to evaluate the effectiveness and tolerability of esomeprazole and omeprazole in patients with gastroesophageal reflux disease (GERD). Electronic searches on PubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov databases were carried out for reports up to February 28, 2015. Ten eligible studies from 8 articles were found that enrolled a total of 10,286 patients for meta-analysis.

Waghray A, Waghray N, Perzynski AT, Votruba M, Wolfe MM. Optimal Omeprazole Dosing and Symptom Control: A Randomized Controlled Trial (OSCAR Trial). Dig Dis Sci. 2019 Jan;64(1):158-166. doi: 10.1007/s10620-018-5235-9. 

Abstract. The objective of this study was to determine whether patients with persistent GERD symptoms on suboptimal omeprazole dosing experience symptomatic improvement when randomized to commonly recommended dosing regimen and to evaluate the economic impact of suboptimal PPI dosing in GERD patients.

Eosinophilic Esophagitis: Treatment With Different Doses of Omeprazole in Children Under 16 Years.
Gómez Torrijos E, Donado Palencia P, Sanchez Miranda MP, Moreno Lozano L, Extremera Ortega AM, Borja Segade JM, Galindo Bonilla PA, García Rodríguez R.
J Investig Allergol Clin Immunol. 2018 Jun;28(3):191-192. doi: 10.18176/jiaci.0230.

Gómez Torrijos E, Donado Palencia P, Sanchez Miranda MP, Moreno Lozano L, Extremera Ortega AM, Borja Segade JM, Galindo Bonilla PA, García Rodríguez R. Eosinophilic Esophagitis: Treatment With Different Doses of Omeprazole in Children Under 16 Years. J Investig Allergol Clin Immunol. 2018 Jun;28(3):191-192. doi: 10.18176/jiaci.0230.

Sicurezza

Wu WT, Tsai CT, Chou YC, Ku PM, Chen YC, You SL, Hung CF, Sun CA. Cardiovascular Outcomes Associated With Clinical Use of Citalopram and Omeprazole: A Nationwide Population-Based Cohort Study. J Am Heart Assoc. 2019 Oct 15;8(20):e011607. doi: 10.1161/JAHA.118.011607.

Abstract. The aim of this study was to evaluate the associations between clinical use of citalopram and omeprazole and the risk of sudden cardiac arrest (SCA) in an Asian population. Methods and Results A retrospective cohort study was conducted using the National Health Insurance Research Database of Taiwan dated from 2000 to 2013. The study cohorts comprised 3882 patients with citalopram use alone, 31 090 patients with omeprazole use alone, and 405 patients with concomitant use of citalopram and omeprazole (as the exposed cohort), and 141 508 patients received treatment with antidepressants without the risk of SCA and/or proton pump inhibitors other than omeprazole (as the comparison cohort).

Lu CX, Zheng BW, Bai B, Hu JL, Fan SF, Shang DF, Yang D, Zhao CL, Cang SD. Effect of omeprazole on plasma concentration and adverse reactions of capecitabine in patients with colon cancer. Zhonghua Zhong Liu Za Zhi. 2019 Sep 23;41(9):708-711 doi: 10.3760/cma.j.issn.0253-3766.2019.09.012.

Abstract. To investigate the effect of omeprazole on plasma concentration, efficacy and adverse reactions of capecitabine in patients with colon cancer.

Jurakić Tončić R, Balić A, Pavičić B, Žužul K, Petković M, Bartolić L, Ljubojević Hadžavdić S. Occupational Airborne Contact Dermatitis Caused by Omeprazole. Acta Dermatovenerol Croat. 2019 Sep;27(3):188-189.

Abstract. Airborne contact dermatitis (ACD) is a frequent condition, and there has been increasing recognition of the occupational origin of airborne contact dermatitis. ACD caused by drugs is often occupation-related and occurs mainly in healthcare workers who use the drugs for therapeutic aims and employees of pharmaceutical industries involved in the production of the drugs...