Bisoprololo, un derivato del fenossi-2-propanolo,  è  un farmaco ampiamente usato per curare l'insufficienza cardiaca cronica come base libera o base coniugata di bisoprololo fumarato ...

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Bisoprololo, un derivato del fenossi-2-propanolo,  è  un farmaco ampiamente usato per curare l'insufficienza cardiaca cronica come base libera o base coniugata di bisoprololo fumarato in forma transdermica, compresse.

E' un beta-bloccante anche utilizzato nel trattamento di ipertensione, fibrillazione atriale,  sindrome da tachicardia posturale, angina e aritmia.

I farmaci antipertensivi sotto forma di cerotti transdermici in particolare sono considerati clinicamente significativi in quanto consentono un controllo stabile della pressione diastolica (1).

Esercita un'attività antiossidante e, per la sua natura lipofilica agevola il passaggio nel tessuto cerebrale per produrre azioni terapeutiche sui neuroni centrali (2)

In un confronto, la tollerabilità, l'efficacia e la sicurezza del bisoprololo e del carvedilolo non mostrano tra loro significative differenze (3).

Come tutti i farmaci può causare effetti collaterali. Consultare sempre il medico.

Bisoprololo studi

Formula molecolare: C₁₈H₃₁NO₄

Peso molecolare: 325.4 g/mol

CAS: 66722-44-9

EC Number: 615-996-8

DSSTox Substance ID: DTXSID6022682

MDL number MFCD00865795

PubChem Substance ID 329757631

Sinonimi:

• Bisoprololum
• Cardicor
• Bisocor
• Detensiel
• Emconcor
• Euradal
• Soloc
• Monocor
• Emcor
• Isoten
• Soprol
• 1-(4-((2-isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol
• [2-hydroxy-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propyl](propan-2-yl)amine
• (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol
• (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol
• 1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol
• 1-[(1-methylethyl)amino]-3-({4-[({2-[(1-methylethyl)oxy]ethyl}oxy)methyl]phenyl}oxy)propan-2-ol
• 1-(propan-2-ylamino)-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol
• 1-(4-[(2-Isopropoxyethoxy)methyl]phenoxy)-3-(isopropylamino)-2-propanol #
• 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-
• 1-[4-(2-isopropoxyethoxymethyl)phenoxy]-3-(isopropylamino)propan-2-ol
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-
• (.+/-.)-1-[[.alpha.-(2-Isopropoxyethoxy)-p-tolyl]oxy]-3-(isopropylamino)-2-propanol
• 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-
• 3-(4-{[2-(methylethoxy)ethoxy]methyl}phenoxy)-1-[(methylethyl)amino]propan-2-o l

Bibliografia_________________________________________________

(1) EFFECT OF HYDROPHILIC AND HYDROPHOBIC POLYMER ON IN VITRO DISSOLUTION AND PERMEATION OF BISOPROLOL FUMARATE THROUGH TRANSDERMAL PATCH.  Shabbir M, Ali S, Raza M, Sharif A, Akhtar FM, Manan A, Fazli AR, Younas N, Manzoor I.  Acta Pol Pharm. 2017 Jan;74(1):187-197.

(2) Quantification of Bisoprolol and Metoprolol in Simultaneous Human Serum and Cerebrospinal Fluid Samples.  Sigaroudi A, Kinzig M, Wahl O, Stelzer C, Schroeter M, Fuhr U, Holzgrabe U, Sörgel F.  Pharmacology. 2018;101(1-2):29-34. doi: 10.1159/000480091.

(3) Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction　- The CIBIS-J Trial.  Tsutsui H, Momomura SI, Masuyama T, Saito Y, Komuro I, Murohara T, Kinugawa S; CIBIS-J Investigators.  Circ J. 2019 May 24;83(6):1269-1277. doi: 10.1253/circj.CJ-18-1199.

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