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 | "Descrizione" by CarPas (5225 pt) | 2020-Mar-01 11:02 |
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Methylsulfonylmethane or Dimethyl sulfone or MSM is an organic compound sulphur-containing that belongs to a class of chemical components called sulfones and is used as a dietary supplement to improve the signs of aging.
It's a metabolite found in human cerebrospinal fluid and blood plasma. It comes from food sources such as fruits, vegetables, cereals, milk, the metabolism of human endogenous methanetiol and intestinal bacterial metabolism (1).
This study has shown that methylsulfonylmethane is effective in reducing visual signs of skin aging even at low doses of 1 g/d. (2).
It is a potential drug for the inhibition of cortisol (cortisol is a hormone involved in stress during exercise) in the skeletal muscle cells of racehorses (3).
Methylsulfonylmethane could promote differentiation and osteogenic potential of stem cells from exfoliated deciduous human dental cells. This osteogenic property is most evident in the presence of mineralized bone particles (4).
MSM in a low dose (200 mM) is able to reduce the migration and invasion of prostate cancer cells (5).
Methylsulfonylmethane. What scientific research says
Molecular Formula: C2H6O2S
Molecular Weight: 325.4 g/mol
CAS: 67-71-0
EC Number: 200-665-9
DSSTox Substance ID: DTXSID4043937
UNII 9H4PO4Z4FT
Synonyms:
References_________________________________________________
(1) Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional (1)H and two-dimensional (1)H-(13)C NMR. Engelke UF, Tangerman A, Willemsen MA, Moskau D, Loss S, Mudd SH, Wevers RA. NMR Biomed. 2005 Aug;18(5):331-6.
(2) Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing. Muizzuddin N, Benjamin R. Int J Vitam Nutr Res. 2020 Feb 21:1-10. doi: 10.1024/0300-9831/a000643.
(3) Methylsulfonylmethane inhibits cortisol-induced stress through p53-mediated SDHA/HPRT1 expression in racehorse skeletal muscle cells: A primary step against exercise stress. Sp N, Kang DY, Kim DH, Lee HG, Park YM, Kim IH, Lee HK, Cho BW, Jang KJ, Yang YM. Exp Ther Med. 2020 Jan;19(1):214-222. doi: 10.3892/etm.2019.8196.
(4) Methylsulfonylmethane increases osteogenesis and regulates the mineralization of the matrix by transglutaminase 2 in SHED cells. Aljohani H, Senbanjo LT, Chellaiah MA. PLoS One. 2019 Dec 5;14(12):e0225598. doi: 10.1371/journal.pone.0225598.
(5) Methylsulfonylmethane (organic sulfur) induces apoptosis and decreases invasiveness of prostate cancer cells. Kowalska K, Habrowska-Górczyńska DE, Domińska K, Urbanek KA, Piastowska-Ciesielska AW. Environ Toxicol Pharmacol. 2018 Dec;64:101-111. doi: 10.1016/j.etap.2018.10.001.
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