La letteratura scientifica si è molto interessata alla lattoferrina in questi ultimi anni ed il riconoscimento della dizione "nutraceutico" è arrivato dopo anni di ricerca. La lattoferrina viene proposta come indicazione terapeutica per svariate patologie.

Li HY, Yang HG, Wu HM, Yao QQ, Zhang ZY, Meng QS, Fan LL, Wang JQ, Zheng N. Inhibitory effects of lactoferrin on pulmonary inflammatory processes induced by lipopolysaccharide through modulating the TLR4-related pathway. J Dairy Sci. 2021 Apr 7:S0022-0302(21)00490-2. doi: 10.3168/jds.2020-19232.

Pal S, Sayeed M, Kumar A, Verma DP, Harioudh MK, Verma NK, Porwal K, Sharma S, Kulkarni C, Bandyopadhyay A, Mugale MN, Mitra K, Ghosh JK, Chattopadhyay N. Self-Assembling Nano-Globular Peptide from Human Lactoferrin Acts as a Systemic Enhancer of Bone Regeneration: A Novel Peptide for Orthopedic Application. ACS Appl Mater Interfaces. 2021 Apr 8. doi: 10.1021/acsami.1c01513. 

Suleman Ismail Abdalla S, Katas H, Chan JY, Ganasan P, Azmi F, Fauzi MB. Gelatin Hydrogels Loaded with Lactoferrin-Functionalized Bio-Nanosilver as a Potential Antibacterial and Anti-Biofilm Dressing for Infected Wounds: Synthesis, Characterization, and Deciphering of Cytotoxicity. Mol Pharm. 2021 Apr 6. doi: 10.1021/acs.molpharmaceut.0c01033. 

Mehta KJ. Role of iron and iron-related proteins in mesenchymal stem cells: Cellular and clinical aspects. J Cell Physiol. 2021 Apr 5. doi: 10.1002/jcp.30383. 

Elizarova A, Sokolov A, Kostevich V, Kisseleva E, Zelenskiy E, Zakharova E, Panasenko O, Budevich A, Semak I, Egorov V, Pontarollo G, De Filippis V, Vasilyev V. Interaction of Lactoferrin with Unsaturated Fatty Acids: In Vitro and In Vivo Study of Human Lactoferrin/Oleic Acid Complex Cytotoxicity. Materials (Basel). 2021 Mar 25;14(7):1602. doi: 10.3390/ma14071602.

Lactoferrin is broadly active against yeasts and highly synergistic with amphotericin B.
Fernandes KE, Weeks K, Carter DA.
Antimicrob Agents Chemother. 2020 Feb 24. pii: AAC.02284-19. doi: 10.1128/AAC.02284-19.

Warding Off Recurrent Yeast and Bacterial Vaginal Infections: Lactoferrin and Lactobacilli.
Superti F, De Seta F.
Microorganisms. 2020 Jan 17;8(1). pii: E130. doi: 10.3390/microorganisms8010130.

Whey Protein and Its Components Lactalbumin and Lactoferrin Affect Energy Balance and Protect against Stroke Onset and Renal Damage in Salt-Loaded, High-Fat Fed Male Spontaneously Hypertensive Stroke-Prone Rats.
Singh A, Zapata RC, Pezeshki A, Knight CG, Tuor UI, Chelikani PK.
J Nutr. 2019 Dec 27. pii: nxz312. doi: 10.1093/jn/nxz312.

Protective effects of the combination Bifidobacterium longum plus lactoferrin against NSAID-induced enteropathy.
Fornai M, Pellegrini C, Benvenuti L, Tirotta E, Gentile D, Natale G, Ryskalin L, Colucci R, Piccoli E, Ghelardi E, Blandizzi C, Antonioli L.
Nutrition. 2020 Feb;70:110583. doi: 10.1016/j.nut.2019.110583.

Effect of bovine lactoferrin as a novel therapeutic agent in a rat model of sepsis-induced acute lung injury.
Han N, Li H, Li G, Shen Y, Fei M, Nan Y.
AMB Express. 2019 Oct 31;9(1):177. doi: 10.1186/s13568-019-0900-8.

Lactoferrin promotes bile acid metabolism and reduces hepatic cholesterol deposition by inhibiting the farnesoid X receptor (FXR)-mediated enterohepatic axis.
Ling CJ, Xu JY, Li YH, Tong X, Yang HH, Yang J, Yuan LX, Qin LQ.
Food Funct. 2019 Nov 1;10(11):7299-7307. doi: 10.1039/c9fo01616c.

The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria.
Vega-Bautista A, de la Garza M, Carrero JC, Campos-Rodríguez R, Godínez-Victoria M, Drago-Serrano ME.
Int J Mol Sci. 2019 Sep 23;20(19). pii: E4707. doi: 10.3390/ijms20194707

Lactoferrin Alleviates the Progression of Atherosclerosis in ApoE-/- Mice Fed with High-Fat/Cholesterol Diet Through Cholesterol Homeostasis.
Ling CJ, Min QQ, Yang JR, Zhang Z, Yang HH, Xu JY, Qin LQ.
J Med Food. 2019 Oct;22(10):1000-1008. doi: 10.1089/jmf.2018.4389.