Flurbiprofen is a derivative of propionic acid and.

It appears as white powder insoluble in water.

What it is used for and where

Medical

Take only under medical supervision

It is a non-steroidal anti-inflammatory analgesic drug (NSAID) water insoluble used as a moderate pain reliever, antipyretic and to treat symptoms of chronic arthritis.

It's a fluorinated drug with potential applications in a large number of pathologies and it is used at low dosage and is commonly found in over-the-counter products both in tablets and sprays. The most common formulation is 8.75mg for use as a symptomatic relief of viral, bacterial or unknown aetiology pharyngitis.

In research on patients undergoing intravenous sedation in oral and maxillo-facial surgery, flurbiprofen axetil was found to be the second most common effective and safe sedation method (1).

by suppressing the inflammatory response of the host, and not only its mediators such as prostanoids, cytokines, Flurbiprofen has the ability to alter the progression of periodontitis but also inhibits osteoclast activity and bone resorption (2).

Flurbiprofen axetil might reduce postoperative delirium in patients over 70 years undergoing major noncardiac surgery (3).

Like all drugs it can cause side effects. Always ask the physician.

Flurbiprofen insights

Appearance	White powder
Boiling Point	376.2±30.0°C at 760 mmHg
Melting Point	110-112°C(lit.)
Flash Point	181.3±24.6°C
Density	1.2±0.1 g/cm3
PSA	37.30000
LogP	4.11
Refraction Index	1.568
Vapor Pressure	0.0±0.9 mmHg at 25°C
Safety

• Molecular Formula : C₁₅H₁₃FO₂
• Linear Formula C₆H₅C₆H₃(F)CH(CH₃)CO₂H 
• Molecular Weight: 244.26 g/mol
• Exact Mass    244.089951
• CAS: 5104-49-4
• EC Number: 225-827-6  257-262-6
• IUPAC  2-(3-fluoro-4-phenylphenyl)propanoic acid
• InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)  
• InChl Key      SYTBZMRGLBWNTM-UHFFFAOYSA-N
• SMILES CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
• DSSTox Substance ID: DTXSID0037231
• MDL number  MFCD00079303  
• PubChem Substance ID 329749901
• NACRES NA.24
• NSC    757037    685701

Synonyms: 

• Ansaid
• L-790,330
• Froben
• (+-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid
• Antadys
• Flurofen
• 3-Fluoro-4-phenylhydratropic acid
• 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid
• 2-(2-fluorobiphenyl-4-yl)propanoic acid

References____________________________________________________

(1) Wang F, YY, Guan M, et al. Pechino Da Xue Xo Yi Xue Ban. 2020;52(1):181–186.

(2) Williams RC, Jeffcoat MK, Howell TH, Rolla A, Stubbs D, Teoh KW, Reddy MS, Goldhaber P. Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen. J Periodontol. 1989 Sep;60(9):485-90.

(3) Wang X, Wang Y, Hu Y, et al. Effect of flurbiprofen axetil on postoperative delirium for elderly patients. Brain Behav. 2019;9(6):e01290. doi:10.1002/brb3.1290