Updates on Flurbiprofen concern use, interactions with other drugs, contraindications.

Khizer Z, Nirwan JS, Conway BR, Ghori MU. Okra (Hibiscus esculentus) gum based hydrophilic matrices for controlled drug delivery applications: Estimation of percolation threshold [published online ahead of print, 2020 Mar 30]. Int J Biol Macromol. 2020;S0141-8130(20)32814-2. doi:10.1016/j.ijbiomac.2020.03.227

Abstract. This study aims to explore the potential of gum extracted from okra fruit (Hibiscus esculentus) in developing hydrophilic matrices for controlled drug release applications, including determination of its percolation threshold. Flurbiprofen (poorly soluble), theophylline (sparingly soluble) and metformin (freely soluble) were employed as model drugs and incorporated using direct compression into matrices containing 40% w/w of three drugs with different physicochemical properties. 

Yang Z, Song Q, Cao Z, et al. Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease. Bioorg Med Chem. 2020;28(7):115374. doi:10.1016/j.bmc.2020.115374

Abstract. A series of novel flurbiprofen-clioquinol hybrids were designed and synthesized as multifunctional agents for Alzheimer's disease therapy, and their potential was evaluated through various biological experiments.

Wang D, Yang SK, Zhao MX, et al. Low dose of flurbiprofen axetil decrease the rate of acute kidney injury after operation: a retrospective clinical data analysis of 9915 cases. BMC Nephrol. 2020;21(1):52. Published 2020 Feb 14. doi:10.1186/s12882-020-1711-5

Abstract. Flurbiprofen axetil (FA) is a commonly prescribed agent to relieve perioperative pain, but the relationship between FA and postoperative acute kidney injury (AKI) remains unclear. This study attempted to evaluate the effects of different dose of perioperative FA on postoperative AKI.

Caban-Toktas S, Sahin A, Lule S, et al. Combination of Paclitaxel and R-flurbiprofen loaded PLGA nanoparticles suppresses glioblastoma growth on systemic administration. Int J Pharm. 2020;578:119076. doi:10.1016/j.ijpharm.2020.119076

Abstract. Malignant gliomas are highly lethal. Delivering chemotherapeutic drugs to the brain in sufficient concentration is the major limitation in their treatment due to the blood-brain barrier (BBB). Drug delivery systems may overcome this limitation and can improve the transportation through the BBB. Paclitaxel is an antimicrotubule agent with effective anticancer activity but limited BBB permeability. R-Flurbiprofen is a nonsteroidal antienflammatory drug and has potential anticancer activity. Accordingly, we designed an approach combining R-flurbiprofen and paclitaxel and positively-charged chitosan-modified poly-lactide-co-glycolic acid (PLGA) nanoparticles (NPs) and to transport them to glioma tissue. 

Alalwani A, Buhara O, Tüzüm MŞ. Oral Health-Related Quality of Life and the Use of Oral and Topical Nonsteroidal Anti-Inflammatory Drugs for Pericoronitis. Med Sci Monit. 2019;25:9200–9206. Published 2019 Dec 3. doi:10.12659/MSM.918085

Abstract. BACKGROUND. Pericoronitis is inflammation of the tissue surrounding a third molar, or wisdom tooth. This study aimed to evaluate the effects of oral and topical analgesic nonsteroidal anti-inflammatory drugs (NSAIDs) on oral health-related quality of life (OHQoL), in terms of oral health and lifestyle, in patients with symptomatic pericoronitis. MATERIAL AND METHODS. The study included 60 patients who presented with pericoronitis and who did not undergo surgery within the following seven days...

Richy F, Rabenda V, Mawet A, Reginster JY. Flurbiprofen in the symptomatic management of rheumatoid arthritis: a valuable alternative. Int J Clin Pract. 2007 Aug;61(8):1396-406. doi: 10.1111/j.1742-1241.2007.01452.x.

Abstract. The withdrawal of certain cyclooxygenase-2 selective drugs and the availability of over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) have increased the pressure for researching and prescribing conventional NSAIDs with a favourable efficacy/tolerance ratio in inflammatory diseases, particularly rheumatoid arthritis. The aim of this comprehensive meta-analysis was to evaluate the absolute and relative efficacy and safety of flurbiprofen in the management of rheumatoid arthritis...

Yilmaz Ö, Bayer B, Bekçi H, et al. Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (type II) [published online ahead of print, 2019 Jun 13]. Med Chem.

Abstract. Prostate cancer is still one of the serious causes of mortality and morbidity in men. Despite recent advances in anticancer therapy, there is a still need of novel agents with more efficacy and specificity in the treatment of prostate cancer. Because of its function on angiogenesis and overexpression in the prostate cancer, methionine aminopeptidase-2 (MetAP-2) has been a potential target for novel drug design recently.

Contraindications

Zhao X, Ji L. Flurbiprofen axetil: Analgesic effect and adverse reaction. Pak J Pharm Sci. 2018;31(3(Special)):1163–1167.

Abstract. Flurbiprofen axetil is a targeted analgesic and non steroidal analgesic with lipid microspheres as drug carrier. It can selectively accumulate in surgical incision and reduce the allodynia a caused by surgical trauma. In this paper, the experimental subjects were divided into three groups to analyze the difference in the analgesic effect of different doses of flurbiprofen axetil for postoperative analgesia. The patients in group A, B and C were treated with flurbiprofen axetil injection 100, 150, 200mg, respectively. The results showed that MAP, HR, static and dynamic VAS scores and postoperative pain incidence in group B and group C were lower than those in group A, and B group had better analgesic effect and lower incidence of adverse reactions. In the future, we should continue to explore the correlation between the effect of flurbiprofen axetil for postoperative analgesia on coagulation function and the range of dose safety.

Yi EM, Leech E. Topical flurbiprofen toxicosis in a cat. J Vet Emerg Crit Care (San Antonio). 2017;27(6):707–712. doi:10.1111/vec.12638