Compendium of the most significant studies with reference to properties, intake, effects.

Piromchai P, Laohakittikul C, Khunnawongkrit S, Srirompotong S. Cerumenolytic Efficacy of 2.5% Sodium Bicarbonate Versus Docusate Sodium: A Randomized, Controlled Trial. Otol Neurotol. 2020 Aug;41(7):e842-e847. doi: 10.1097/MAO.0000000000002672.

Abstract. To evaluate the efficacy of 2.5% sodium bicarbonate and docusate sodium in patients with complete occlusion of the ear canal from impacted cerumen.

Dioctyl Sulfosuccinate or Docusate (Calcium or Sodium) for the Prevention or Management of Constipation: A Review of the Clinical Effectiveness [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Jun 26.

Abstract.  This review was undertaken to determine the clinical effectiveness of docusate for the prevention or management of constipation.

Edenfield AL, Siddiqui NY, Wu JM, Dieter AA, Garrett MA, Visco AG. Polyethylene Glycol 3350 and Docusate Sodium Compared With Docusate Sodium Alone After Urogynecologic Surgery: A Randomized Controlled Trial. Obstet Gynecol. 2016 Sep;128(3):543-9. doi: 10.1097/AOG.0000000000001565.

Abstract. To compare time to first bowel movement and additional gastrointestinal outcomes between women receiving polyethylene glycol 3350 (PEG3350) and docusate sodium and docusate sodium alone after urogynecologic surgery.

Hogue DR, Zimmardi JA, Shah KA. High-performance liquid chromatographic analysis of docusate sodium in soft gelatin capsules. J Pharm Sci. 1992 Apr;81(4):359-61. doi: 10.1002/jps.2600810414.

Abstract.  A rapid and simple high-performance liquid chromatographic (HPLC) method for the analysis of docusate sodium in soft gelatin capsules was developed with progesterone as the internal standard.

 Meruva S, Thool P, Gong Y, Karki S, Bowen W, Kumar S. Role of wetting agents and disintegrants in development of danazol nanocrystalline tablets. Int J Pharm. 2020 Mar 15;577:119026. doi: 10.1016/j.ijpharm.2020.119026. 

Abstract. The objective of this study was to evaluate the effect of wetting agents and disintegrants on the dissolution performance of dried nanocrystals of an active pharmaceutical ingredient (API) with poor wetting property.

Glowicz J, Crist M, Gould C, Moulton-Meissner H, Noble-Wang J, de Man TJB, Perry KA, Miller Z, Yang WC, Langille S, Ross J, Garcia B, Kim J, Epson E, Black S, Pacilli M, LiPuma JJ, Fagan R; B. cepacia Investigation Workgroup. A multistate investigation of health care-associated Burkholderia cepacia complex infections related to liquid docusate sodium contamination, January-October 2016. Am J Infect Control. 2018 Jun;46(6):649-655. doi: 10.1016/j.ajic.2017.11.018.

Abstract. This incident demonstrates that lapses in manufacturing practices and quality control of nonsterile liquid drugs can have serious unintended consequences.