Frankly, the presence of a decidedly "unhealthy" ingredient that could therefore cause health problems in a medicine is surprising. The only explanation maybe is the dated formulation and not updated with recent studies. On the other hand, unfortunately, until the ingredient (Titanium Dioxide is banned in some European countries but not yet in Italy and yet it is present in many medicines) will not be banned also in Italy, there is nothing to do. Pharmaceutical companies answer: excipient approved by the competent Authority.

18-4-2021 Today I wrote these comments to the EMA (European Medicines Agency) and to Europe Direct Contact Center asking for a written response.

4-6-2021 Response: 

Regarding titanium dioxide, the European Food Safety Authority published its opinion on May 6, 2021 and concluded that, based on all available evidence, a concern for genotoxicity cannot be ruled out, and given the many uncertainties, E 171 can no longer be considered safe when used as a food additive. As mentioned in a tweet on the same day, following EFSA's new scientific opinion on the food additive E171, we will propose to ban its use in the EU. https://twitter.com/food_eu/status/1390347410476523521

Regarding medicinal products, the Commission has asked the European Medicines Agency to assess the effect on the use of TiO2 in medicinal products and the feasibility of alternatives to replace TiO2, if possible, without impact on the quality, safety and efficacy of medicinal products. A decision will be made by the Commission based on the analysis provided by the Agency."

All we can do is hope and wait (how much?).