Magnesium Gluconate is a chemical compound, organometallic pharmaceutical salt of magnesium with gluconic acid. Gluconic acid is a weak organic acid that is derived from the oxidation or dehydrogenation of glucose found in honey, fruit.

In medicine it is an organometallic pharmaceutical antioxidant compound used for the prevention and treatment of hypomagnesemia as a source of magnesium ions (1). 

Magnesium gluconate has important properties for the prevention and treatment of cardiovascular disease (2), is neuroprotective (3), can help in cases of ischemia/reperfusion injury (4).

It is used as a food additive with the function of acidity regulator.

In cosmetics it functions as a skin firming agent (5).

It also has strong chelating properties to the anions of copper, iron, calcium, aluminum and many other heavy metals.

Magnesium gluconate studies

Molecular Formula : C₁₂H₂₂MgO₁₄    C₁₂H₂₂MgO₁₄ · xH₂O    Mg(HOCH₂(CHOH)₄CO₂)₂

Molecular Weight: 414.60 g/mol

CAS: 3632-91-5

UNII TH52F4317B

EC Number: 222-848-2

DSSTox Substance ID: 24895362

MDL number  MFCD00150971

PubChem Substance ID 

NACRES:  NA.25

Sinonimi: 

• D-Gluconic acid magnesium salt
• D-Gluconic acid hemimagnesium salt
• Magnesium gluconate anhydrous
• Magnesium gluconate hydrate
• Almora

References___________________________________________________________________

(1) Trivedi MK, Dixit N, Panda P, Sethi KK, Jana S. In-depth investigation on physicochemical and thermal properties of magnesium (II) gluconate using spectroscopic and thermoanalytical techniques. J Pharm Anal. 2017 Oct;7(5):332-337. doi: 10.1016/j.jpha.2017.03.006.

(2) Gums JG. Magnesium in cardiovascular and other disorders. Am J Health Syst Pharm. 2004 Aug 1;61(15):1569-76. doi: 10.1093/ajhp/61.15.1569. 

(3) Turner RJ, Dasilva KW, O'Connor C, van den Heuvel C, Vink R. Magnesium gluconate offers no more protection than magnesium sulphate following diffuse traumatic brain injury in rats. J Am Coll Nutr. 2004 Oct;23(5):541S-544S. doi: 10.1080/07315724.2004.10719399. 

(4) Weglicki William B.. INTRAVENOUS MAGNESIUM GLUCONATE FOR TREATMENT OF CONDITIONS CAUSED BY EXCESSIVE OXIDATIVE STRESS DUE TO FREE RADICAL DISTRIBUTION. European Patent Office Publ. of Application with search report EP19970905624. 24 Jan 1997.

(5)  Mahendra Kumar Trivedi, Neena Dixit, Parthasarathi Panda, Kalyan Kumar Sethi, Snehasis Jana, In-depth investigation on physicochemical and thermal properties of magnesium (II) gluconate using spectroscopic and thermoanalytical techniques, Journal of Pharmaceutical Analysis, Volume 7, Issue 5, 2017, Pages 332-337, ISSN 2095-1779, https://doi.org/10.1016/j.jpha.2017.03.006. (https://www.sciencedirect.com/science/article/pii/S2095177917300254) Abstract: Magnesium gluconate is a classical organometallic pharmaceutical compound used for the prevention and treatment of hypomagnesemia as a source of magnesium ion. The present research described the in-depth study on solid state properties viz. physicochemical and thermal properties of magnesium gluconate using sophisticated analytical techniques like PXRD, PSA, FT-IR, UV–Vis spectroscopy, TGA/DTG, and DSC. Magnesium gluconate was found to be crystalline in nature along with the crystallite size ranging from 14.10 to 47.35nm. The particle size distribution was at d(0.1)=6.552µm, d(0.5)=38.299µm, d(0.9)=173.712µm and D(4,3)=67.122µm along with the specific surface area of 0.372m2/g. The wavelength for the maximum absorbance was at 198.0nm. Magnesium gluconate exhibited 88.51% weight loss with three stages of thermal degradation process up to 895.18°C from room temperature. The TGA/DTG thermograms of the analyte indicated that magnesium gluconate was thermally stable up to around 165°C. Consequently, the melting temperature of magnesium gluconate was found to be 169.90°C along with the enthalpy of fusion of 308.7J/g. Thus, the authors conclude that the achieved results from this study are very useful in pharmaceutical and nutraceutical industries for the identification, characterization and qualitative analysis of magnesium gluconate for preformulation studies and also for developing magnesium gluconate based novel formulation.